108516-23-0Relevant articles and documents
Investigations into the C-deuteriation of aryl alkyl ketones using urea as a pro-base in the presence of a deuterium donor
Coumbarides, Gregory S.,Eames, Jason,Suggate, Michael J.,Weerasooriya, Neluka
, p. 641 - 652 (2006)
Results are reported on the regioselective C-deuteriation of a series of enolates derived from the deprotonation of aryl alkyl ketones using dilithiated urea as the pro-base in the presence of a suitable deuterium donor. Copyright
Catalytic asymmetric synthesis of (S)-oxybutynin and a versatile intermediate for antimuscarinic agents
Masumoto, Shuji,Suzuki, Masato,Kanai, Motomu,Shibasaki, Masakatsu
, p. 10497 - 10504 (2007/10/03)
A practical synthesis of (S)-oxybutynin, a muscarinic receptor antagonist, using catalytic enantioselective cyanosilylation of cyclohexyl phenyl ketone (9a) as a key step is described. The key reaction proceeded with 94% ee using 1 mol% of Gd-1 catalyst,
Investigations into the regioselective C-deuteration of acyclic and exocyclic enolates
Eames, Jason,Coumbarides, Gregory S.,Suggate, Michael J.,Weerasooriya, Neluka
, p. 634 - 641 (2007/10/03)
Results are reported on the regioselective C-deuteration of a series of related acyclic and exocyclic enolates derived from substituted aryl ketones. We comment on factors, such as the presence of additives and the structural nature of the enolate, that influence the observed C-deuteration and discuss the role of the deuterium donor. ( Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2003).