108540-72-3

Upstream product

• 589-15-1 1-bromomethyl-4-bromobenzene 
• 1068-90-2 2-acetylaminomalonic acid diethyl ester 
• 1262785-54-5 t-butyl 3-(4-bromophenyl)-2-(diphenylmethyleneamino)propanoate 
• 71078-92-7 diethyl (acetylamino)<(4-bromophenyl)methyl>propanedioate 

Downstream Products

• 132153-48-1 N-(tert-Butyloxycarbonyl)-4-bromo-DL-phenylalanine 
• 71131-95-8 4-[3-Oxo-3-piperidin-1-yl-2-(toluene-4-sulfonylamino)-propyl]-benzamidine; hydriodide 
• 80853-61-8 4-[3-Oxo-3-piperidin-1-yl-2-(toluene-4-sulfonylamino)-propyl]-benzimidic acid ethyl ester; hydrochloride 
• 71079-02-2 4-[3-Oxo-3-piperidin-1-yl-2-(toluene-4-sulfonylamino)-propyl]-thiobenzimidic acid methyl ester; hydriodide 
• 71078-66-5 4-[3-Oxo-3-piperidin-1-yl-2-(toluene-4-sulfonylamino)-propyl]-benzamidine; hydrochloride 
• 71078-96-1 N_α-Tosyl-4-cyanphenylalaninpiperidid 
• 71079-01-1 4-[3-oxo-3-piperidin-1-yl-2-(toluene-4-sulfonylamino)-propyl]-thiobenzamide 
• 71078-95-0 N-[1-(4-Bromo-benzyl)-2-oxo-2-piperidin-1-yl-ethyl]-4-methyl-benzenesulfonamide 
• 84895-12-5 2-{4-Methoxy-3-[4-((E)-2-methoxycarbonyl-vinyl)-phenoxy]-phenyl}-4-oxo-3,4,6,7,9,10,11,12,14,15-decahydro-2H,5H-1,4a,8,13-tetraaza-benzocyclotridecene-8,13-dicarboxylic acid 13-tert-butyl ester 8-(2,2,2-trichloro-ethyl) ester 
• 84877-92-9 2-{4-Methoxy-3-[4-((Z)-2-methoxycarbonyl-vinyl)-phenoxy]-phenyl}-4-oxo-3,4,6,7,9,10,11,12,14,15-decahydro-2H,5H-1,4a,8,13-tetraaza-benzocyclotridecene-8,13-dicarboxylic acid 13-tert-butyl ester 8-(2,2,2-trichloro-ethyl) ester 
• 84877-93-0 13-Acetyl-2-{4-methoxy-3-[4-((Z)-2-methoxycarbonyl-vinyl)-phenoxy]-phenyl}-4-oxo-2,3,4,6,7,9,10,11,12,13,14,15-dodecahydro-5H-1,4a,8,13-tetraaza-benzocyclotridecene-8-carboxylic acid 2,2,2-trichloro-ethyl ester 
• 84878-01-3 (Z)-3-{4-[5-(1-tert-Butoxycarbonylamino-2-methoxycarbonyl-ethyl)-2-methoxy-phenoxy]-phenyl}-acrylic acid methyl ester 
• 84877-91-8 (Z)-3-{4-[5-(1-Amino-2-methoxycarbonyl-ethyl)-2-methoxy-phenoxy]-phenyl}-acrylic acid methyl ester 
• 84878-00-2 3-(4'-bromophenyl)-(Z)-propenoic acid methyl ester 

Relevant academic research and scientific papers

DUAL-ACTING OXAZOLE ANTIHYPERTENSIVE AGENTS

In one aspect, the invention relates to compounds having the formula: wherein: Ar, Z, R3, R4 and R5 are as defined in the specification, or a pharmaceutically acceptable salt thereof. These compounds have AT1 re

Generation of N-Methyl-D-aspartate Agonist and Competitive Antagonist Pharmacophore Models. Design and Synthesis of Phosphonoalkyl-Substituted Tetrahydroisoquinolines as Novel Antagonists

The preparation and binding affinity of a series of tetrahydroisoquinoline carboxylic acids at the N-methyl-D-aspartate (NMDA) subtype of the glutamate receptor is described, together with a molecular modeling analysis of NMDA agonists and antagonists.Usi

Synthesis and antitumor activity of platinum(II) complexes containing substituted ethylenediamine ligands

The synthesis of substituted ethylenediamines, their reactions with K2PtCl4 to give the dichloroplatinum(II) complexes, and the exchange of the chloro ligands for other leaving groups are described.The new compounds have been tested as antitumor agents both in vitro using the hormone independent human mammary carcinoma cell line MDA-MB 231 as well as in vivo using the lymphocytic P388 leukemia of the CD2F1-mouse.In the P388 test, 53 of the 55 tested complexes fulfill the minimum activity of 125percent T/C required for a substance to be active.