1085411-78-4

Basic information

• Product Name: (E)-2-(4-methoxy-2-styryl-phenyl)pyridine
• Synonyms: (E)-2-(4-methoxy-2-styryl-phenyl)pyridine
• CAS NO: 1085411-78-4
• Molecular Weight: 287.361
• Mol File: 1085411-78-4.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: (E)-2-(4-methoxy-2-styryl-phenyl)pyridine(CAS DataBase Reference)
• NIST Chemistry Reference: (E)-2-(4-methoxy-2-styryl-phenyl)pyridine(1085411-78-4)
• EPA Substance Registry System: (E)-2-(4-methoxy-2-styryl-phenyl)pyridine(1085411-78-4)

Safety Data

• Hazardous Substances Data: 1085411-78-4(Hazardous Substances Data)

Upstream product

• 5957-90-4 4-(2-pyridinyl)anisole 
• 140-10-3 (E)-3-phenylacrylic acid 
• 536-74-3 phenylacetylene 

Relevant articles and documents

Acetic Acid-Promoted Rhodium(III)-Catalyzed Hydroarylation of Terminal Alkynes

Rhodium(III)-catalyzed hydroarylation of terminal alkynes has not previously been achieved because of the inevitable oligomerization and other side reactions. Here, we report a novel Cp?Rh(III)-catalyzed hydroarylation of terminal alkynes in acetic acid as solvent to facilitate the C-H bond activation and subsequent transformations. This reaction proceeds under mild conditions, providing an effective approach to the synthesis of alkenylated heterocycles in high to excellent yields (31-99%) with a broad substrate scope (37 examples) and good functional-group compatibility. In this transformation, the loading of the alkyne can be reduced to 1.2 equivalents, which indicates the significant role of HOAc in lowering the reaction temperature and suppressing the oligomerization of the terminal alkyne. Preliminary mechanistic studies are also presented.

RuCl3-catalyzed alkenylation of aromatic C-H bonds with terminal alkynes

(Chemical Equation Presented) RuCl3-catalyzed regio- and/or stereoselective alkenylation reactions of a variety of arylpyridines proceeded efficiently with terminal alkynes or allylic compounds in the presence of benzoyl peroxide or benzoic acid.