108545-58-0Relevant academic research and scientific papers
HOMOLYTIC DISPLACEMENT AT SATURATED CARBON CENTRE: SYNTHESIS OF BENZYLSULPHONES
Gupta, B. D.,Kumar, Manoj,Das, Indira,Roy, M.
, p. 5773 - 5776 (1986)
The reactions of benzyl cobaloximes with p-substitued benzene sulphonyl chlorides under photochemical conditions from benzyl sulphones by novel SH2 process.
Aryl alkyl, aryl aryl thioether compound and its synthesis method
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Paragraph 0163-0166, (2017/08/16)
The invention discloses a synthesis method of an aryl-alkyl and aryl-aryl thioether compound represented by a formula (III). According to the synthesis method, aryl tetrafluoroboric acid diazonium salt is taken as a reaction raw material in a reaction solvent, aryl and alkyl thiosulfate is taken as a sulfurizing agent, and the materials react under the catalysis action of visible light and a photosensitive agent to obtain the aryl-alkyl and aryl-aryl thioether compound. According to the synthesis method, the raw materials are easy to obtain and are cheap, the reaction operation is simple, the reaction condition is mild and environment-friendly, the yield is higher, the functional group tolerance is excellent, later modification of drugs is successfully realized, and an efficient C-S bond construction method is provided for medicinal chemistry and biological orthogonal chemistry research.
Homolytic Displacement at Saturated Carbon in Organocobalamines. Part 4
Gupta, B. Dass,Roy, Maheswar,Roy, Sujit,Kumar, Manoj,Das, Indira
, p. 537 - 543 (2007/10/02)
Benzyl and para-substituted benzylcobaloximes react with substituted arenesulphonyl chlorides under photochemical and anaerobic conditions at 0 deg C to give a variety of products including the sulphones, bibenzyls, and benzyl ethers of dimethylglyoxime in variable yields.However, when the reactions are carried out in the presence of a 1 mol excess of pyridine, the yield of sulphones is increased by at least 20percent in each case.The corresponding yield of bibenzyls is decreased and no trace of the benzyl ether of dimethylglyoxime is formed.On the other hand, the reaction of heteroaromatic methyl cobaloximes with arenesulphonyl chlorides form the corresponding sulphones as the exclusive organic product in good yield and with no side products.The reactions are interpreted in terms of a direct attack of the arenesulphonyl radical on the α carbon of the benzyl and heteroaromatic methyl ligand.
