108546-66-3Relevant academic research and scientific papers
SYNTHESIS OF 2,3-DISUBSTITUTED CYCLOPENT-2-EN-1-ONES FROM 6-METHOXYINDANONE
Moody, Christopher J.,Toczek, Judy
, p. 1397 - 1400 (2007/10/02)
A new route to 2,3-disubstituted cyclopentenones (4) is described.Reductive alkylation of 6-methoxyindanone (1) in potassium and liquid ammonia followed by addition of lithium bromide and an alkyl halide gives dihydroindanones (2).Ozonolysis of the dihydroindanones results in cleavage of the vinyl ether double bond, and oxidation of the resulting aldehyde (3) leads to the 2,3-disubstituted cyclopentenones (4), after spontaneous decarboxylation of the intermediate β-keto acid.
A NEW USE OF THE BIRCH REDUCTION. SYNTHESIS OF 2,3-DISUBSTITUTED CYCLOPENT-2-EN-1-ONES FROM 6-METHOXYINDANONE
Moody, Christopher J.,Toczek, Judy
, p. 5253 - 5254 (2007/10/02)
Reductive alkylation of 6-methoxyindanone (1) gives the dihydroindanones (2), ozonolysis and oxidation of which leads directly to 2,3-disubstituted cyclopent-2-en-1-ones (4).
