108546-78-7

Usage

Chemical structure

A cyclopropane ring and a carboxylic acid functional group, with a hydroxyphenylmethyl group attached.

Hydroxyphenylmethyl group

A benzene ring with a hydroxyl group attached to a carbon atom, connected to a methyl group.

Derivative

A modified version of cyclopropane carboxylic acid, with the addition of a hydroxyphenylmethyl group.

Potential applications

Medicinal chemistry and pharmaceutical research, due to the presence of the hydroxyphenylmethyl group.

Unique properties

The hydroxyphenylmethyl group may confer unique properties to the molecule, which could be beneficial in various applications.

Further research

Additional studies may be needed to fully understand the chemical and biological characteristics of 1-(hydroxyphenylmethyl)cyclopropanecarboxylic acid.

Upstream product

• 79172-43-3 1-benzoylcyclopropanecarboxylic acid 
• 100-52-7 benzaldehyde 
• 108546-72-1 2,6-di(tert-butyl)-4-methylphenyl 1-(α-hydroxybenzyl)cyclopropanecarboxylate 

Relevant academic research and scientific papers

Hepatitis C Virus Inhibitors

The present disclosure is generally directed to antiviral compounds, and more specifically directed to combinations of compounds which can inhibit the function of the NS5A protein encoded by Hepatitis C virus (HCV), compositions comprising such combinations, and methods for inhibiting the function of the NS5A protein.

COMBINATIONS OF HEPATITIS C VIRUS INHIBITORS

The present disclosure is generally directed to antiviral compounds, and more specifically directed to combinations of compounds which can inhibit the function of the NS5A protein encoded by Hepatitis C virus (HCV), compositions comprising such combinations, and methods for inhibiting the function of the NS5A protein.

Generation and Reactions of Lithiated tert-Butyl and 2,6-Di(tert-butyl)-4-methylphenyl Cyclopropanecarboxylates

tert-Butyl and 2,6-di(tert-butyl)-4-methylphenyl (BHT) cyclopropanecarboxylates (4, 6, 24, 25) are lithiated with LiN(i-Pr)2 and t-BuLi, respectively.Reactions with alkyl halides, aldehydes, acyl chlorides, and heteroelectrophiles give α-substituted BHT esters which can be cleaved (t-BuOK/H2O/THF) to the corresponding carboxylic acids or reduced (LiAlH4/THF) to the cyclopropanemethanols.