1085709-02-9

Basic information

• Product Name: 3-[4-amino-5-(methylthio)-4H-1,2,4-triazol-3-yl]-1-phenyl-9H-β-carboline
• Synonyms: 3-[4-amino-5-(methylthio)-4H-1,2,4-triazol-3-yl]-1-phenyl-9H-β-carboline
• CAS NO: 1085709-02-9
• Molecular Weight: 372.453
• Mol File: 1085709-02-9.mol

Chemical Properties

• CAS DataBase Reference: 3-[4-amino-5-(methylthio)-4H-1,2,4-triazol-3-yl]-1-phenyl-9H-β-carboline(CAS DataBase Reference)
• NIST Chemistry Reference: 3-[4-amino-5-(methylthio)-4H-1,2,4-triazol-3-yl]-1-phenyl-9H-β-carboline(1085709-02-9)
• EPA Substance Registry System: 3-[4-amino-5-(methylthio)-4H-1,2,4-triazol-3-yl]-1-phenyl-9H-β-carboline(1085709-02-9)

Safety Data

• Hazardous Substances Data: 1085709-02-9(Hazardous Substances Data)

Upstream product

• 1085708-98-0 1-phenyl-3-(4-amino-5-thioxo-1,2,4-triazol-3-yl) β-carboline 
• 74-88-4 methyl iodide 
• 1085708-98-0 3-(4-amino-5-mercapto-4H-1,2,4-triazol-3-yl)-1-phenyl-9H-β-carboline 

Relevant articles and documents

Synthesis and Antitumor Activity of Novel 1-Substituted 3-(4,5-Substituted 1,2,4-Triazol-3-yl)-β-carboline Derivatives

Schiff bases, 1,2,4-triazolo[4,3-d[[1,2,3,4]thiatriazoles, and 1,2,4-triazolo[3,4-b[[1,3,4]thiadiazoles carrying the β-carboline nucleus were synthesized from 3-(4-amino-5-mercapto-1,2,4-triazol-3-yl)-β-carbolines. The compounds were evaluated for their in vitro antitumor activity against eight human cancer cell lines. The 1,2,4-triazolo[4,3-d[[1,2,3,4]thiatriazole derivatives showed a broad spectrum of antitumor activity, with GI 50 values lower than 13 μM for all cell lines tested. In general, all tested compounds showed potent activity against the breast (MCF-7) cancer cell line, with GI 50 values in the range of 2.07 to 4.58 μM.

Synthesis and antitumoral activity of novel 3-(2-substituted-1,3,4-oxadiazol-5-yl) and 3-(5-substituted-1,2,4-triazol-3-yl) β-carboline derivatives

Several novel 1-substituted-phenyl β-carbolines bearing the 2-substituted-1,3,4-oxadiazol-5-yl and 5-substituted-1,2,4-triazol-3-yl groups at C-3 were synthesized and evaluated for their in vitro anticancer activity. The assay results pointed thirteen compounds with growth inhibition effect (GI50 50 values lying in the nanomolar concentration range (GI50 = 10 nM for both compounds). The 1-(N,N-dimethylaminophenyl)-3-(5-thioxo-1,2,4-triazol-3-yl) β-carboline (8g) was the most active compound, showing particular effectiveness on lung (GI50 = 0.06 μM), ovarian and renal cell lines. The potent anticancer activity presented for synthesized compounds 7a, 7h, and 8g, together with their easiness of synthesis, makes these compounds promising anticancer agents.