1085709-12-1Relevant articles and documents
Synthesis and biological evaluation of a novel class of β-carboline derivatives
Chen, Hao,Gao, Pengchao,Zhang, Meng,Liao, Wei,Zhang, Jianwei
, p. 4155 - 4166 (2014)
In this study, several novel β-carboline derivatives, 1-(4-hydroxy-3-methoxyphenyl)-β-carboline-3-carboxyl-Trp-Trp-AA-OBzl compounds, were designed and synthesized as potential anticancer agents. Their in vitro cytotoxic activities were evaluated using me
Discovery of novel phosphatidylcholine-specific phospholipase C drug-like inhibitors as potential anticancer agents
Barker, David,Brar, Harpreet Kaur,Eurtivong, Chatchakorn,Leung, Euphemia,Leung, Ivanhoe K. H.,Paulin, Emily K.,Pilkington, Lisa I.,Rees, Shaun,Reynisson, Jóhannes,Sharma, Nabangshu,White, Reuben M.,Xu, Chris Sun,van Rensburg, Michelle
supporting information, (2019/12/24)
Phosphatidylcholine–specific phospholipase C (PC-PLC) is a promising target for new anticancer treatment. Herein, we report our work in the discovery of novel drug-like PC-PLC inhibitors. Virtual screening led to the identification of promising hits from
COMPOUNDS FOR TREATMENT OF METABOLIC SYNDROME
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Page/Page column 45; 46, (2012/10/18)
Present invention refers to new compounds of formula I or II, its synthesis and its use in the treatment of metabolic syndrome, particularly for the treatment of type I or type II diabetes and/or metabolic syndrome or metabolic disease or metabolic disorders.
Synthesis and antitumoral activity of novel 3-(2-substituted-1,3,4-oxadiazol-5-yl) and 3-(5-substituted-1,2,4-triazol-3-yl) β-carboline derivatives
Formagio, Anelise S. Nazari,Tonin, Lilian T. Duesman,Foglio, Mary Ann,Madjarof, Christiana,de Carvalho, Joao Ernesto,da Costa, Willian Ferreira,Cardoso, Flavia P.,Sarragiotto, Maria Helena
scheme or table, p. 9660 - 9667 (2009/04/06)
Several novel 1-substituted-phenyl β-carbolines bearing the 2-substituted-1,3,4-oxadiazol-5-yl and 5-substituted-1,2,4-triazol-3-yl groups at C-3 were synthesized and evaluated for their in vitro anticancer activity. The assay results pointed thirteen compounds with growth inhibition effect (GI50 50 values lying in the nanomolar concentration range (GI50 = 10 nM for both compounds). The 1-(N,N-dimethylaminophenyl)-3-(5-thioxo-1,2,4-triazol-3-yl) β-carboline (8g) was the most active compound, showing particular effectiveness on lung (GI50 = 0.06 μM), ovarian and renal cell lines. The potent anticancer activity presented for synthesized compounds 7a, 7h, and 8g, together with their easiness of synthesis, makes these compounds promising anticancer agents.