108583-53-5

Upstream product

• 534-22-5 2-methylfuran 
• 408536-04-9 2-methyl-5-sulfamoyl-furan-3-carboxylic acid amide 
• 69815-95-8 5-methylfuran-2-sulfonyl chloride 
• 1017264-48-0 5-bromofuran-2-sulfonamide 
• 823-96-1 Trimethylboroxine 
• 67-64-1 acetone 
• 473935-67-0 C₁₁H₁₀Cl₆N₂O₇S 

Relevant academic research and scientific papers

SULFONYLUREAS AND RELATED COMPOUNDS AND USE OF SAME

ABSTRACT The present invention provides for certain sulfonyl ureas and related compounds which have advantageous properties and show useful activity in the inhibition of activation of the NLRP3 inflammasome. Such compounds are useful in the treatment of a wide range of disorders in which the inflammation process, or more specifically the NLRP3 inflammasome, have been implicated as being a key factor.

Sulfonamide derivatives

Compounds of formula (I) as well as pharmaceutically acceptable salts and esters thereof, wherein L, R1, R2, m and n have the meaning given in claim 1 and which can be used in the form of pharmaceutical compositions.

A mild, efficient method for the synthesis of aromatic and aliphatic sulfonamides

A two-step method was developed for the synthesis of aromatic and aliphatic sulfonamides from the corresponding sulfinates using bis(2,2,2-trichloroethyl)azodicarboxylate as the electrophilic nitrogen source. The intermediate sulfonylhydrazides were obtained in very good yields and were cleaved under reductive conditions to deliver the desired sulfonamides. A variety of substituents in the aromatic ring are well tolerated as well as heterocycles.