1085965-72-5Relevant articles and documents
METASTIN DERIVATIVE AND USE THEREOF
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, (2017/06/28)
The present invention provides a metastin derivative represented by the formula (I): wherein each symbol is as defined in the specification, or a salt thereof, or a pharmaceutical composition containing it. The metastin derivative or a salt thereof is superior in blood stability, and has a cancer metastasis suppressive action or cancer growth suppressive action.
METASTIN DERIVATIVE AND USE THEREOF
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, (2011/04/13)
The present invention provides a metastin derivative represented by the formula (I): wherein each symbol is as defined in the specification, or a salt thereof, or a pharmaceutical composition containing it. The metastin derivative or a salt thereof is sup
Development of novel G-protein-coupled receptor 54 agonists with resistance to degradation by matrix metalloproteinase
Tomita, Kenji,Oishi, Shinya,Ohno, Hiroaki,Peiper, Stephen C.,Fujii, Nobutaka
supporting information; experimental part, p. 7645 - 7649 (2009/12/07)
Kisspeptin-GPR54 signaling is involved in the suppression of cancer metastasis and regulation of hormonal secretion. Recently, matrix metalloproteinase mediated deactivation of kisspeptins through hydrolysis of the Gly-Leu peptide bond has been reported.