1086-02-8

Basic information

• Product Name: PYRIDINITRIL
• Synonyms: 2,6-dichlor-4-phenylpyridin-3,5-dicarbonitril;2,6-dichloro-4-phenyl-5-pyridinedicarbonitrile;2,6-dichloro-4-phenylpyridinedicarbonitrile-3,5;culvan;ddpp;it-3296;2,6-DICHLORO-4-PHENYLPYRIDINE-3,5-DICARBONITRILE;PYRIDINITRIL
• CAS NO: 1086-02-8
• Molecular Formula: C₁₃H₅Cl₂N₃
• Molecular Weight: 274.1
• EINECS: 214-119-2
• Mol File: 1086-02-8.mol
• Article Data: 2

Chemical Properties

• Melting Point: 203-204 °C
• Boiling Point: 447.3 °C at 760 mmHg
• Flash Point: 224.3 °C
• Appearance: /
• Density: 1.48 g/cm³
• Vapor Pressure: 3.4E-08mmHg at 25°C
• Refractive Index: 1.657
• PKA: -8.78±0.10(Predicted)
• CAS DataBase Reference: PYRIDINITRIL(CAS DataBase Reference)
• NIST Chemistry Reference: PYRIDINITRIL(1086-02-8)
• EPA Substance Registry System: PYRIDINITRIL(1086-02-8)

Safety Data

• Hazardous Substances Data: 1086-02-8(Hazardous Substances Data)

Usage

General Description

Pyridinitril, also known as pyridine-2-carbonitrile, is a chemical compound with the formula C6H4N2. It is a colorless liquid that is soluble in water and has a strong odor similar to that of pyridine. Pyridinitril is commonly used as a precursor in the synthesis of pharmaceuticals, dyes, and agricultural chemicals. It is also used as a corrosion inhibitor in metalworking and as a solvent in the production of rubber and resins. Pyridinitril is considered to be potentially harmful if ingested or inhaled, and precautions should be taken to avoid exposure to this chemical.

InChI:InChI=1/C13H5Cl2N3/c14-12-9(6-16)11(8-4-2-1-3-5-8)10(7-17)13(15)18-12/h1-5H

Upstream product

• 67720-42-7 2-hydroxy-6-amino-4-phenylpyridine-3,5-dicarbonitrile 
• 96583-92-5 6-amino-2-chloro-4-phenylpyridine-3,5-dicarbonitrile 

Downstream Products

• 157139-76-9 ethyl 3,5-diamino-4-phenyldithieno<3',2'-e:2,3-b>pyridine-2,6-dicarboxylate 
• 1322622-18-3 2,6-bis(N,N-dimethylamino)-4-phenylpyridine-3,5-dicarbonitrile 
• 1456626-37-1 2-((4-(1-benzylpiperidin-4-yl)butyl)amino)-6-chloro-4-phenylpyridine-3,5-dicarbonitrile 
• 1456626-36-0 2-((3-(1-benzylpiperidin-4-yl)propyl)amino)-6-chloro-4-phenylpyridine-3,5-dicarbonitrile 
• 1456626-34-8 2-((2-(1-benzylpiperidin-4-yl)ethyl)amino)-6-chloro-4-phenylpyridine-3,5-dicarbonitrile 
• 1456626-35-9 2,6-bis((2-(1-benzylpiperidin-4-yl)ethyl)amino)-4-phenylpyridine-3,5-dicarbonitrile 
• 1335032-53-5 2-((1-benzylpiperidin-4-yl)amino)-6-chloro-4-phenylpyridine-3,5-dicarbonitrile 
• 1335032-31-9 2-((1-benzylpiperidin-4-yl)amino)-4-phenyl-6-(prop-2-yn-1-ylamino)pyridine-3,5-dicarbonitrile 
• 1335032-28-4 2-((3-(1-benzylpiperidin-4-yl)propyl)amino)-6-(methyl(prop-2-yn-1-yl)amino)-4-phenylpyridine-3,5-dicarbonitrile 
• 1335032-26-2 2-((2-(1-benzylpiperidin-4-yl)ethyl)amino)-6-(methyl(prop-2-yn-1-yl)amino)-4-phenylpyridine-3,5-dicarbonitrile 
• 1335032-24-0 2-(((1-benzylpiperidin-4-yl)methyl)amino)-6-(methyl(prop-2-yn-1-yl)amino)-4-phenylpyridine-3,5-dicarbonitrile 
• 1335032-22-8 2-((1-benzylpiperidin-4-yl)amino)-6-(methyl(prop-2-yn-1-yl)amino)-4-phenylpyridine-3,5-dicarbonitrile 
• 1335032-56-8 2,6-bis((1-benzylpiperidin-4-yl)amino)-4-phenylpyridine-3,5-dicarbonitrile 
• 1335032-41-1 2-chloro-6-(methyl(prop-2-yn-1-yl)amino)-4-phenylpyridine-3,5-dicarbonitrile 

Relevant articles and documents

Synthesis and biological evaluation of 3,6-diamino-1H-pyrazolo[3,4-b]pyridine derivatives as protein kinase inhibitors

The synthesis and biological evaluation of a number of differently substituted 3,6-diamino-1H-pyrazolo[3,4-b]pyridine derivatives are reported. From the inhibition results on a selection of disease-relevant protein kinases [IC50 (μM) DYRK1A = 11; CDK5 = 0.41; GSK-3 = 1.5] we have observed that 3,6-diamino-4-phenyl-1H-pyrazolo[3,4-b]pyridine-5-carbonitrile (4) constitutes a potential new and simple lead compound in the search of drugs for the treatment of Alzheimer's disease.