1086007-35-3

Upstream product

• 7355-58-0 N-(2-chloro-ethyl)-acetamide 
• 612-23-7 2-nitrobenzyl chloride 
• 1086096-22-1 2-chloro-N-(2-nitrobenzyl)ethanamine 
• 75-36-5 acetyl chloride 
• 1086007-30-8 N-(2-chloroethyl)-2-nitrobenzylamine hydrochloride 

Downstream Products

• 57756-36-2 4-Acetyl-2,3,4,5-tetrahydro-1H-1,4-benzodiazepin 

Relevant academic research and scientific papers

Simple synthesis process of anxiolytic drug lorazepam intermediate

The invention discloses a simple synthesis process of an anxiolytic drug lorazepam intermediate. The simple synthesis process comprises the steps of putting N-(2-chloroethyl)acetamide, triethylamine and dichloromethane into a reaction bottle; stirring the

Process for Preparing 4-Acetyl-2,3,4,5-tetrahydro-benzo[1,4]diazepine and the Intermediates Thereof

The present invention relates to a process for preparing 4-acetyl-2,3,4,5-tetrahydro-benzo[1,4]diazepine and the intermediates thereof. The present invention provides a compound represented by formula I and a compound represented by formula II, and proces

PREPARATION METHODS OF 4-ACETYL-2,3,4,5-TETRAHYDRO- BENZO[1,4]DIAZEPINE AND THEIR INTERMEDIATES

The present invention relates to a process for preparing 4-acetyl-2,3,4,5-tetrahydrobenzo[1,4]diazepine and the intermediates thereof. The present invention provides a compound represented by formula I and a compound represented by formula II, and processes for preparing 4-acetyl-2,3,4,5-tetrahydro-benzo[1,4]diazepine by using the compound represented by formula I, the compound represented by formula II and o-nitrobenzaldehyde. The invention has the advantages of the shorter synthesis steps, easily available raw materials and simple operation. Moreover, the process is economic and safe by avoiding the use of expensive and dangerous lithium aluminium hydride.