108608-61-3Relevant academic research and scientific papers
Structural Determinants of the Selectivity of 3-Benzyluracil-1-acetic Acids toward Human Enzymes Aldose Reductase and AKR1B10
Ruiz, Francesc X.,Cousido-Siah, Alexandra,Porté, Sergio,Domínguez, Marta,Crespo, Isidro,Rechlin, Chris,Mitschler, André,De Lera, ángel R.,Martín, María Jesús,De La Fuente, Jesús ángel,Klebe, Gerhard,Parés, Xavier,Farrés, Jaume,Podjarny, Alberto
, p. 1989 - 2003 (2015)
The human enzymes aldose reductase (AR) and AKR1B10 have been thoroughly explored in terms of their roles in diabetes, inflammatory disorders, and cancer. In this study we identified two new lead compounds, 2-(3-(4-chloro-3-nitrobenzyl)-2,4-dioxo-3,4-dihy
POLYBROMINATED AROMATIC COMPOUNDS V. REACTION OF PENTABROMOTOLUENE WITH SODIUM METHOXIDE IN PYRIDINE
Shishkin, V. N.,Lapin, K. K.,Tanaseichuk, B. S.,Butin, K. P.
, p. 1882 - 1887 (2007/10/02)
During the reaction of pentabromotoluene with sodium methoxide in pyridine, together with the products from methoxydebromination and protodebromination, the products from substitution of both the bromine atom in the aromatic ring and hydrogen atom in the methyl group by methoxy groups are formed.The directing effect of the methyl and methoxymethyl groups during substitution of the bromine in the pentabromophenyl ring by the methoxide ion was studied, and it was shown that the directing selectivity of these substituents is low.The methyl group is predominantly a meta-orientant, whereas the methoxymethyl group is predominantly a para-orientant.
