108608-61-3Relevant articles and documents
Structural Determinants of the Selectivity of 3-Benzyluracil-1-acetic Acids toward Human Enzymes Aldose Reductase and AKR1B10
Ruiz, Francesc X.,Cousido-Siah, Alexandra,Porté, Sergio,Domínguez, Marta,Crespo, Isidro,Rechlin, Chris,Mitschler, André,De Lera, ángel R.,Martín, María Jesús,De La Fuente, Jesús ángel,Klebe, Gerhard,Parés, Xavier,Farrés, Jaume,Podjarny, Alberto
, p. 1989 - 2003 (2015)
The human enzymes aldose reductase (AR) and AKR1B10 have been thoroughly explored in terms of their roles in diabetes, inflammatory disorders, and cancer. In this study we identified two new lead compounds, 2-(3-(4-chloro-3-nitrobenzyl)-2,4-dioxo-3,4-dihy
