108610-78-2Relevant academic research and scientific papers
High bulk density, crystalline 3-cyano-2-morpholino-5-pyrid-4-yl)-pyridine
-
, (2008/06/13)
A method for preparing high bulk density crystalline 3-cyano-2-morpholino-5-(pyrid-4-yl)-pyridine which comprises precipitating a high bulk density crystaline 3-cyano-2-morpholino-5-(pyrid-4-yl)-pyridine from a starting material that is (a) a solution in an inorganic or organic acid, and precipitating with a base, or (b) a solution in a chlorinated hydrocarbon, and precipitating with an aliphatic hydrocarbon, or (c) from an aliphatic ester of an aliphatic carboxylic acid and an aliphatic alcohol. The compact, crystalline 3-cyano-2-morpholino-5-(pyrid-4-yl)-pyridine, so obtained, has a bulk density of from about 220 to about 360 g/l and is most suitable for pharmaceutical preparations.
Potential cardiotonic agents. Part 14: Synthesis and positive inotropic activities of 2-morpholino-5-(4-pyridinyl)pyridines
Hagen,Hagen,Krause,Klauschenz
, p. 767 - 769 (2007/10/02)
By the reaction of 2-chloro-5-(4-pyridinyl)pyridines 1-6 with morpholine as well as by derivation of the 2-morpholino-pyridine-3-carboxamide 8 the 3-substituted 2-morpholino-5-(4-pyridinyl)pyridines 7-14 were prepared. The evaluation for positive inotropic properties in spontaneously beating isolated guinea pig atria gave for the 3-cyano derivative 7 (AWD 122-14) the best activity. The potency is comparable to that of milrinone and is due to partial inhibition of phosphodiesterase III (PDE III).
