1086391-06-1

Basic information

• Product Name: Methyl 3-bromoindazole-5-carboxylate
• Synonyms: Methyl 3-bromoindazole-5-carboxylate;Methyl 3-bromoindazole-5-...;Methyl 3-BroMo-1H-indazole-5-carboxylate;Methyl 3-broMoindazol-5-carboxylate;methyl 3-bromo-2H-indazole-5-carboxylate
• CAS NO: 1086391-06-1
• Molecular Formula: C₉H₇BrN₂O₂
• Molecular Weight: 255.06808
• Mol File: 1086391-06-1.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 399.7±22.0 °C(Predicted)
• Appearance: /
• Density: 1.709
• PKA: 10.62±0.40(Predicted)
• CAS DataBase Reference: Methyl 3-bromoindazole-5-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: Methyl 3-bromoindazole-5-carboxylate(1086391-06-1)
• EPA Substance Registry System: Methyl 3-bromoindazole-5-carboxylate(1086391-06-1)

Safety Data

• Hazardous Substances Data: 1086391-06-1(Hazardous Substances Data)

Usage

General Description

Methyl 3-bromoindazole-5-carboxylate is a chemical compound that belongs to the class of indazoles. It is a derivative of indazole and contains a methyl ester group as well as a bromine atom at the 3-position of the indazole ring. Methyl 3-bromoindazole-5-carboxylate has potential applications in the field of organic synthesis and pharmaceutical research due to its structural features and reactivity. Its unique properties make it a valuable building block for the synthesis of various organic molecules, which may have biological activity or other important functions. The compound may be used as a precursor in the synthesis of pharmaceutical compounds and other organic materials.

InChI:InChI=1S/C9H7BrN2O2/c1-14-9(13)5-3-2-4-6-7(5)8(10)12-11-6/h2-4H,1H3,(H,11,12)

Upstream product

• 473416-12-5 methyl 1H-indazole-5-carboxylate 
• 61700-61-6 1H-indazole-5-carboxylic acid 

Downstream Products

• 885223-58-5 3-methyl-1H-indazole-5-carboxylic acid 

Relevant articles and documents

Catalyst-Free 1,2-Dibromination of Alkenes Using 1,3-Dibromo-5,5-dimethylhydantoin (DBDMH) as a Bromine Source

A direct 1,2-dibromination method of alkenes is realized using 1,3-dibromo-5,5-dimethylhydantoin (DBDMH) as a bromine source. This reaction proceeds under mild reaction conditions without the use of a catalyst and an external oxidant. Various sorts of alkene substrates are transformed into the corresponding 1,2-dibrominated products in good to excellent yields with broad substrate scope and exclusive diastereoselectivity. This method offers a green and practical approach to synthesize vicinal dibromide compounds.

N-ARYLYLMETHYLINDAZOLE MODULATORS OF PPARG

The invention provides molecular entities that bind with high affinity to PPARG (PPARy), inhibit cdJk5-mediated phosphorylation of PP ARG, but do not exert an agonistic effect on PPARG. Compounds of the invention can be used for treatment of conditions in patients wherein PPARG plays a role, such as diabetes or obesity. Methods of preparation of the compounds, bioassay methods for evaluating compounds of the invention as non-agonistic PPARG binding compounds, and pharmaceutical compositions are also provided.