108641-77-6Relevant articles and documents
Iridium-Catalyzed Asymmetric Borylation of Unactivated Methylene C(sp3)-H Bonds
Reyes, Ronald L.,Iwai, Tomohiro,Maeda, Satoshi,Sawamura, Masaya
, (2019/05/08)
Herein, we show the highly enantioselective borylation of unactivated methylene C(sp3)-H bonds in 2-alkylpyridines and 2-alkyl-1,3-azole derivatives using an iridium-BINOL-based chiral monophosphite catalyst system. Quantum chemical calculations using the artificial force induced reaction (AFIR) method suggested that a monophosphite-Ir-tris(boryl) complex generates a narrow chiral reaction pocket where the differentiation of the enantiotopic methylene C-H bonds is accomplished through an assembly of multiple noncovalent interactions.
ORGANOLITHIUM AND ORGANOSODIUM COMPOUNDS OF N-SUBSTITUTED 2-ALKYLBENZIMIDAZOLES
Tertov, B.A.,Bogachev, Yu.G.,Koshchienko, Yu.V.,Suvorova, G.M.,Tsupak, E.B.,et al.
, p. 868 - 872 (2007/10/02)
Organolithium and organosodium compounds of 1,2-dimethyl-, 1-methyl-2-ethyl-,1-methyl-2-propyl-, and 1-phenyl-2-methylbenzimidazole, containing the metal in the alkyl group at position C(2), were obtaind by metallation.It was found that metallation can be complicated by the addition of metalling reagent at the C=N bond of the heterocycle.It was shown that the obtained organometallic compounds can be used for the synthesis of various derivatives of benzimidazole.