108649-59-8

Basic information

• Product Name: 2 4-DICHLOROPHENETHYL BROMIDE
• Synonyms: 2,4-Dichlorophenethyl broMide 96%;1-(2-Bromoethyl)
• CAS NO: 108649-59-8
• Molecular Formula: C₈H₇BrCl₂
• Molecular Weight: 253.95
• Mol File: 108649-59-8.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 271.622°C at 760 mmHg
• Flash Point: >230 °F
• Appearance: /
• Density: 1.5721 g/mL at 25 °C(lit.)
• Vapor Pressure: 0.011mmHg at 25°C
• Refractive Index: n20/D 1.584(lit.)
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 2 4-DICHLOROPHENETHYL BROMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2 4-DICHLOROPHENETHYL BROMIDE(108649-59-8)
• EPA Substance Registry System: 2 4-DICHLOROPHENETHYL BROMIDE(108649-59-8)

Safety Data

• Hazard Codes: T
• Statements: 25-41
• Safety Statements: 26-39-45
• RIDADR: UN 2810 6.1/PG 3
• WGK Germany: 3
• Hazardous Substances Data: 108649-59-8(Hazardous Substances Data)

Usage

General Description

2,4-Dichlorophenethyl bromide, also known as 2,4-dibromophenethyl bromide, is a chemical compound used as a precursor in the synthesis of various pharmaceuticals and agrochemicals. It is a brominated derivative of phenethyl bromide, and it is commonly used as an intermediate in the production of organic compounds. This chemical is known for its reactivity and ability to undergo various chemical reactions, making it a versatile compound in organic synthesis. It is important to handle 2,4-dichlorophenethyl bromide with caution, as it can be harmful if not handled properly and should be used in a well-ventilated area with appropriate personal protective equipment.

InChI:InChI=1/C8H7BrCl2/c9-4-3-6-1-2-7(10)5-8(6)11/h1-2,5H,3-4H2

Upstream product

• 81156-68-5 2,4-dichlorophenylethyl alcohol 

Downstream Products

• 129254-90-6 1-(2,4-dichlorophenyl)3-(pyridin-4-yl)-butane 
• 1426260-73-2 2-(2,4-dichlorophenethyl)-8-(2,4-dimethoxyphenyl)-6-methoxy-1,2,3,4-tetrahydroisoquinolin-7-ol 
• 1426260-53-8 2-(2,4-dichlorophenethyl)-6-methoxy-1,2,3,4-tetrahydroisoquinolin-7-ol 
• 61019-61-2 1-(2,4-dichlorophenethyl)-1H-imidazole 
• 1578261-43-4 2,4-dichloro-1-(4-methoxyphenethyl)benzene 
• 1443040-00-3 2,4-dichlorophenylethyl azide 
• 1355026-31-1 C₁₄H₁₂Cl₂N₂O₃ 
• 1351938-92-5 1-[2-(2,4-dichlorophenyl)ethyl]-1,2,3,6-tetrahydropyridine hydrochloride 
• 1351938-86-7 1-[2-(2,4-dichlorophenyl)ethyl]-1,2,3,6-tetrahydropyridine 
• 1360869-10-8 Br^(1-)*C₁₃H₁₂Cl₂N⁽¹⁺⁾ 
• 1260521-21-8 C₁₀H₈Cl₂O₃ 
• 1327337-56-3 C₁₀H₁₀Cl₂O₃ 
• 1058856-50-0 C₁₂H₁₄Cl₂O₃ 
• 711017-43-5 sodium 2-(2,4-dichlorophenyl)ethanesulphonate 

Relevant articles and documents

BICYCLIC PYRIMIDIN-4-(3H)-ONES AND ANALOGUES AND DERIVATIVES THEREOF WHICH MODULATE THE FUNCTION OF THE VANILLOID-1 RECEPTOR (VR1)

Compounds of formula (I); which are useful as therapeutic compounds, particularly in the treatment of pain and other conditions ameliorated by the modulation of the function of the vanilloid-1 receptor (VR1).

ATP-citrate lyase as a target for hypolipidemic intervention. Design and synthesis of 2-substituted butanedioic acids as novel, potent inhibitors of the enzyme

ATP-citrate lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. Inhibitors of the enzyme represent a potentially novel class of hypolipidemic agent, which are anticipated to have combined hypocholesterolemic and hypotriglyceridemic properties. A series of 2-substituted butanedioic acids have been designed and synthesized as inhibitors of the enzyme. The best compounds, 58, 68, 71, 74 have reversible K(i)'s in the 1-3 μM range against the isolated rat enzyme. As representative of this compound class, 58, has been shown to exert its inhibitory action through a mainly competitive mechanism with respect to citrate and a noncompetitive one with respect to CoA. None of the inhibitors were able to inhibit cholesterol and/or fatty acid synthesis in HepG2 cells. This has been attributed to the adverse physicochemical properties of the molecules leading to a lack of cell penetration. Despite this, a lead structural class of compound has been identified with the potential for modification into potent, cell-penetrant, and efficacious inhibitors of ATP- citrate lyase.