108655-61-4

Basic information

• Product Name: 4-Isoxazolecarboxylicacid,5-amino-3-(trifluoromethyl)-,methylester(9CI)
• Synonyms: 4-Isoxazolecarboxylicacid,5-amino-3-(trifluoromethyl)-,methylester(9CI);methyl 5-amino-3-(trifluoromethyl)isoxazole-4-carboxylate
• CAS NO: 108655-61-4
• Molecular Formula: C₆H₅F₃N₂O₃
• Molecular Weight: 210.11
• Product Categories: AMINOACID
• Mol File: 108655-61-4.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 297.6±40.0 °C(Predicted)
• Appearance: /
• Density: 1.510±0.06 g/cm3(Predicted)
• PKA: -3.72±0.10(Predicted)
• CAS DataBase Reference: 4-Isoxazolecarboxylicacid,5-amino-3-(trifluoromethyl)-,methylester(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Isoxazolecarboxylicacid,5-amino-3-(trifluoromethyl)-,methylester(9CI)(108655-61-4)
• EPA Substance Registry System: 4-Isoxazolecarboxylicacid,5-amino-3-(trifluoromethyl)-,methylester(9CI)(108655-61-4)

Safety Data

• Hazardous Substances Data: 108655-61-4(Hazardous Substances Data)

Upstream product

• 105-34-0 methyl 2-cyanoacetate 
• 207238-34-4 2-Cyano-4,4,4-trifluoro-3-oxo-butyric acid methyl ester 
• 111246-08-3 1-cyano-1-methoxycarbonyl-2-trifluoromethylethylene 
• 14533-30-3 Trifluoroacetohydroximoyl bromide etherate 

Downstream Products

• 108655-65-8 Methyl 5--3-trifluoromethylisoxazole-4-carboxylate 
• 1094619-88-1 (R)-6-(3-aminopyridin-2-yl)-5-(1-phenylpropan-2-yl)-3-(trifluoromethyl)isoxazolo[5,4-d]pyrimidin-4(5H)-one 
• 1094619-69-8 (R)-2,2,2-trifluoro-N-(2-(4-oxo-5-(1-phenylpropan-2-yl)-3-(trifluoromethyl)-4,5-dihydroisoxazolo[5,4-d]pyrimidin-6-yl)pyridin-3-yl)acetamide 
• 1094619-66-5 (R)-N-(2-(4-oxo-5-(1-phenylpropan-2-yl)-3-(trifluoromethyl)-4,5-dihydroisoxazolo[5,4-d]pyrimidin-6-yl)pyridin-3-yl)acetamide 
• 1094619-87-0 (R)-6-(3-nitropyridin-2-yl)-5-(1-phenylpropan-2-yl)-3-(trifluoromethyl)isoxazolo[5,4-d]pyrimidin-4(5H)-one 
• 108655-64-7 Methyl 5-(dibenzoylamino)-3-trifluoromethylisoxazole-4-carboxylate 
• 1094619-86-9 (R)-5-amino-N-(1-phenylpropan-2-yl)-3-(trifluoromethyl)isoxazole-4-carboxamide 
• 178552-18-6 5-Benzenesulfonylamino-3-trifluoromethyl-isoxazole-4-carboxylic acid 
• 178552-17-5 N-(3-trifluoromethyl-4-methoxycarbonyl-5-isoxazolyl)benzenesulfonamide 
• 108655-63-6 3-(trifluoromethyl)isoxazole-5-amine 
• 108655-68-1 Methyl 5--3-trifluoromethylisoxazole-4-carboxylate 
• 108655-67-0 Methyl 5-<(4-chlorobenzoyl)amino>-3-trifluoromethylisoxazole-4-carboxylate 
• 108655-72-7 6-Methoxy-5-phenyl-3-trifluoromethyl-5H-isoxazolo[5,4-d]pyrimidin-4-one 
• 108655-73-8 7-Methyl-5-phenyl-3-trifluoromethyl-7H-isoxazolo[5,4-d]pyrimidine-4,6-dione 

Relevant articles and documents

A facile synthesis of 5-amino-3-trifluoromethyl-4- methoxycarbonylisoxazole

The title compound was synthesized in 3 steps from readily available cyanoacetate and TFAA. The ester group allowed access to other functionalized isoxazole derivatives.

Synthesis and Reaction of 5-Amino-3-trifluoromethylisoxazole and -pyrazole-4-carboxylic Acids

5-Amino-3-trifluoromethylisoxazole- and -pyrazole-4-carboxylic acids were prepared by the reactions of trifluoroacetonitrile oxide or -imines with cyanoacetic acid derivatives, respectively.The behavior of thus obtained aminoazole-4-carboxylic acids towar