108656-65-1

Basic information

• Product Name: 5-(3-BROMO-PHENYL)-[1,3,4]THIADIAZOL-2-YLAMINE
• Synonyms: 5-(3-BROMOPHENYL)-1,3,4-THIADIAZOL-2-AMINE;5-(3-BROMO-PHENYL)-[1,3,4]THIADIAZOL-2-YLAMINE
• CAS NO: 108656-65-1
• Molecular Formula: C₈H₆BrN₃S
• Molecular Weight: 256.12
• Mol File: 108656-65-1.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 5-(3-BROMO-PHENYL)-[1,3,4]THIADIAZOL-2-YLAMINE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(3-BROMO-PHENYL)-[1,3,4]THIADIAZOL-2-YLAMINE(108656-65-1)
• EPA Substance Registry System: 5-(3-BROMO-PHENYL)-[1,3,4]THIADIAZOL-2-YLAMINE(108656-65-1)

Safety Data

• Hazardous Substances Data: 108656-65-1(Hazardous Substances Data)

Upstream product

• 585-76-2 m-bromobenzoic acid 
• 79-19-6 thiosemicarbazide 
• 3132-99-8 m-bromobenzoic aldehyde 
• 333-20-0 potassium thioacyanate 
• 7420-35-1 3'-bromobenzaldehyde-thiosemicarbazone 

Downstream Products

• 108656-66-2 2-Chloro-5-(3-bromophenyl)-1,3,4-thiadiazole 

Relevant articles and documents

N-(5-phenyl-1, 3, 4-thiadiazole-2-yl) benzamide compound

The invention belongs to the technical field of medicines, relates to a compound with antitumor activity and a specific chemical structure, and in particular relates to an N-((6, 7-dimethoxyquinoline-4-yl) oxy) methyl)-N-(5-phenyl-1, 3, 4-thiadiazole-2-yl) benzamide compound and a preparation method and an application thereof. The structural general formula of the compound is shown in the specification, wherein an R group is mono-substituted or double-substituted phenyl, fluorophenyl, chlorphenyl, bromophenyl, benzyl, benzyloxy, benzene nitro or trifluoromethyl substituted at 2-position, 3-position or 4-position. Pharmacological studies show that the compound provided by the invention has a relatively remarkable proliferation inhibition effect on HER-2 positive breast cancer cells SK-Br-3, the effect is obviously superior to that of HER-2 negative breast cancer cells MCF-7, the compound can be used for preparing antitumor drugs, and a new way is opened up for deep research and development of tumor drugs in the future. The preparation method provided by the invention is simple and feasible, relatively high in yield and easy for large-scale production.

I2 Promoted Synthesis of 2-Aminothiadiazoles Employing KSCN as a Sulfur Source Under Metal-Free Conditions

A new three-component strategy from aldehyde, p-toluenesulfonyl hydrazide and potassium thiocyanate for the synthesis of 2-aminothiadiazoles promoted by I2 under metal-free conditions has been described. Potassium thiocyanate was used as an odo

ORGANIC COMPOUNDS

The present invention relates to compounds and compositions useful for inhibiting and/or reducing platelet deposition, adhesion and/or aggregation. The present invention further relates to methods for the treatment or prophylaxis of thrombotic disorders,