108664-43-3

Basic information

• Product Name: 1-[2-(biphenyl-4-ylcarbonyl)prop-2-en-1-yl]pyridin-2(1H)-one
• Synonyms: 2(1H)-Pyridinone, 1-(2-((1,1'-biphenyl)-4-ylcarbonyl)-2-propenyl)-; 2(1H)-pyridinone, 1-[2-([1,1'-biphenyl]-4-ylcarbonyl)-2-propen-1-yl]-; 2(1H)-Pyridinone, 1-[2-([1,1'-biphenyl]-4-ylcarbonyl)-2-propenyl]-
• CAS NO: 108664-43-3
• Molecular Formula: C₂₁H₁₇NO₂
• Molecular Weight: 315.3652
• Mol File: 108664-43-3.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 564.7°C at 760 mmHg
• Flash Point: 267.2°C
• Density: 1.164g/cm³
• Vapor Pressure: 8.95E-13mmHg at 25°C
• Refractive Index: 1.608
• CAS DataBase Reference: 1-[2-(biphenyl-4-ylcarbonyl)prop-2-en-1-yl]pyridin-2(1H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 1-[2-(biphenyl-4-ylcarbonyl)prop-2-en-1-yl]pyridin-2(1H)-one(108664-43-3)
• EPA Substance Registry System: 1-[2-(biphenyl-4-ylcarbonyl)prop-2-en-1-yl]pyridin-2(1H)-one(108664-43-3)

Safety Data

• Hazardous Substances Data: 108664-43-3(Hazardous Substances Data)

Usage

Chemical structure

The compound has a complex structure that includes a pyridine ring and a biphenyl group.

Usage

It is commonly used as a building block in organic synthesis, particularly in the pharmaceutical industry for the production of various drugs.

Biological activities

The compound exhibits a range of biological activities, including anti-inflammatory and antioxidant properties.

Potential

It is a potential candidate for drug development due to its biological activities.

Reactivity

Its unique structure and versatile reactivity make it an important intermediate in the production of advanced pharmaceuticals and other organic compounds.

Upstream product

• 5409-63-2 1-(4-biphenyl-1-yl)-3-dimethylamino-1-propanone hydrochloride 
• 92-91-1 biphenyl-4-acetaldehyde 

Relevant articles and documents

Synthesis and Antifungal Activity of a Series of Novel 1,2-Disubstituted Propenones

To find an antifungal agent other than those of the imidazole and triazole series, a new class of 1,2-disubstituted propenones I and II was prepared and tested for antifungal activity.Comparison of the structure-activity relationships showed that the conjugated structure of carbonyl and exomethylene groups in I and II plays an important role in potent antifungal acivity.However, it is noteworthy that compounds 53, 54, and 56, which have a hydroxymethyl or methoxymethyl group instead of an exo-methylene group in I, also showed potent activity.Although many compounds exhibited strong antifungal activity in vitro, none showed activity in vivo of oral efficacy against subacute systemic candidiasis in mice. '