5409-63-2

Usage

Type of compound

Ketone

Structure

Biphenyl group attached to the first carbon
Dimethylamino group attached to the third carbon of the propyl chain

Field of application

Organic chemistry

Usage

Synthesis of various pharmaceuticals
Synthesis of organic compounds

Pharmacological properties

Potential use as a psychoactive substance

Hazard

Can be hazardous if not handled properly

Safety precaution

Use with caution

Upstream product

• 92-91-1 biphenyl-4-acetaldehyde 
• 50-00-0 formaldehyd 
• 506-59-2 N,N-dimethylammonium chloride 

Downstream Products

• 35076-77-8 4-cyclopropyl-1,1'-biphenyl 
• 1425336-15-7 1-(biphenyl-4-yl)-3-(5,6-dimethyl-1H-benzimidazol-1-yl)-1-propanone 
• 1425336-12-4 1-(biphenyl-4-yl)-3-(2-methyl-1H-benzimidazol-1-yl)-1-propanone 
• 108664-43-3 1-[2-(Biphenyl-4-carbonyl)-allyl]-1H-pyridin-2-one 
• 108664-39-7 1-Biphenyl-4-yl-2-[1,2,4]triazol-1-ylmethyl-propenone 
• 108664-42-2 1-(4-phenylphenyl)-2-<(1H-pyrazol-1-yl)methyl>-2-propen-1-one 

Relevant academic research and scientific papers

A novel antifungal agent with broad spectrum: 1-(4-Biphenylyl)-3-(1H- imidazol-1-yl)-1-propanone

A series of (1-substituted aryl)-3-(1H-imidazol-1-yl)-1-propanones was synthesized through the N-alkylation of imidazole with 3-dimethylamino-1- (substituted aryl)-1-propanone hydrochlorides (ketonic Mannich bases). A second series of N1-substituted imidazoles was obtained by the reduction of the carbonyl function of the imidazole-ketones in the previous series by means of NaBH4. All of the compounds were evaluated for antifungal activity against 16 strains of Candida, and 3-(1H-imidazol-1-yl)-1-(4-biphenylyl)-1- propanone emerged as a broad-spectrum antifungal agent. Several 3-(1H-imidazol-1-yl)-1-(2′-(substituted benzyl)oxyphenyl)-1-propanones were also active towards Candida kefyr. Copyright

THERAPEUTIC AGENT FOR DIABETES

A therapeutic agent for diabetes, which comprises a compound of the formula [I] wherein Xis a group of the formula wherein R4and R5are the same or different and each is a hydrogen atom, an optionally substituted alkyl having 1 to 5 carbon atoms and the like, and R6is a hydrogen atom or an amino-protecting group; R1is an optionally substituted alkyl having 1 to 5 carbon atoms, an optionally substituted alkenyl having 2 to 6 carbon atoms and the like, R2is a hydrogen atom, an optionally substituted alkyl having 1 to 5 carbon atoms and the like, R2' is a hydrogen atom, and R3is an optionally substituted alkyl having 1 to 5 carbon atoms and the like, a prodrug thereof, a pharmaceutically acceptable salt thereof, a hydrate thereof and a solvate thereof. The compound of the present invention shows superior blood sugar decreasing action on the state of hyperglycemia, but does not affect the blood sugar when it is in the normal range or in the hypoglycemic state, which means that it is free of serious side effects such as hypoglycemia. Therefore, the compound of the present invention is useful as a therapeutic drug for diabetes and also useful as a preventive of the chronic complications of diabetes.

Synthesis and Antifungal Activity of a Series of Novel 1,2-Disubstituted Propenones

To find an antifungal agent other than those of the imidazole and triazole series, a new class of 1,2-disubstituted propenones I and II was prepared and tested for antifungal activity.Comparison of the structure-activity relationships showed that the conjugated structure of carbonyl and exomethylene groups in I and II plays an important role in potent antifungal acivity.However, it is noteworthy that compounds 53, 54, and 56, which have a hydroxymethyl or methoxymethyl group instead of an exo-methylene group in I, also showed potent activity.Although many compounds exhibited strong antifungal activity in vitro, none showed activity in vivo of oral efficacy against subacute systemic candidiasis in mice. '