108694-47-9Relevant academic research and scientific papers
Synthesis of Fluorinated Acridines via Sequential Micellar Buchwald-Hartwig Amination/Cyclization of Aryl Bromides
Vaghi, Luca,Sanzone, Alessandro,Sassi, Mauro,Pagani, Simone,Papagni, Antonio,Beverina, Luca
, p. 1621 - 1628 (2018)
Fluorinated unsymmetrical acridines are efficiently prepared by means of a tandem micellar Buchwald-Hartwig amination followed by an acid-promoted cyclization. The overall process is advantageous with respect to previously described protocols both in terms of efficiency and sustainability. The role of the cosolvent in the amination step is highlighted, demonstrating that rather than resorting to highly expensive catalysts, Buchwald-Hartwig aminations can be straightforwardly carried out by tuning the reaction site polarity.
Nickel-Catalyzed Transformations of 2,1-Benzisoxazoles with Organozinc Reagents
Baum, Jonathan S.,Condon, Michael E.,Shook, David A.
, p. 2983 - 2988 (2007/10/02)
A novel transformation of 2,1-benzisoxazoles (anthranils) involving nitrogen-oxygen bond rupture with concomitant nitrogen-carbon bond formation by reaction with aryl-, methyl, or 2-thienylzinc chlorides in the presence of nickel catalyst is described.The products of the reaction are o-(substituted-amino)benzaldehydes and benzophenones, precursors of a series of heterocyclic derivatives, including acridines, quinolones, and the novel 7-chloro-1,3-dihydro-1,5-diphenyl-2H-1,4-benzodiazepin-2-one (21)
