108715-05-5

Upstream product

• 101089-61-6 acetic acid-(4-methyl-3-phenylsulfanyl-anilide) 
• 103-89-9 4-Methylacetanilide 
• 80-17-1 benzenesufonyl hydrazide 
• 938-10-3 phenylsulfonyl azide 
• 2618-96-4 dibenzenesulfonamide 
• 368-43-4 phenylsulfonyl fluoride 
• 98-11-3 benzenesulfonic acid 
• 98-09-9 benzenesulfonyl chloride 
• 71-43-2 benzene 
• 69267-37-4 3-benzenesulfonyl-4-methyl-aniline 
• 108-24-7 acetic anhydride 
• 860244-42-4 (2-methyl-5-nitro-phenyl)-phenyl sulfone 

Relevant academic research and scientific papers

Complementary Site-Selective Sulfonylation of Aromatic Amines by Superacid Activation

Under superacidic conditions, aniline and indole derivatives are sulfonylated at low temperature with easy-to-access arenesulfonic acids or arenesulfonyl hydrazides. By modification of the functional-group directing effect through protonation, this method allows nonclassical site functionalization by overcoming the innate regioselectivity of electrophilic aromatic substitution. This superacid-mediated sulfonylation of arenes is complementary to existing methods and can be applied, through protection by protonation, to the late-stage site-selective functionalization of natural alkaloids and active pharmaceutical ingredients.