108717-64-2Relevant academic research and scientific papers
Antiproliferative effects of novel urea derivatives against human prostate and lung cancer cells; And their inhibition of β-glucuronidase activity
Perveen, Shahnaz,Mustafa, Sana,Qamar, Kehkashan,Dar, Ahsana,Khan, Khalid M.,Choudhary, Muhammad Iqbal,Khan, Ajmal,Voelter, Wolfgang
, p. 1099 - 1113 (2014/03/21)
Twenty-one novel urea derivatives were synthesized and their structures characterized by mass, NMR, IR, and UV spectroscopy. These compounds were evaluated for their antiproliferative profile against human PC-3 (prostate) and NCI-H460 (lung) cancer cell lines. Among them, compound 21 N-(3-nitrophenyl)- N′-(1-phenylethyl)urea was found to be active against both PC-3 (IC 50 ± SEM: 20.13 ± 0.91 μM) and NCI-H460 (GI 50: 22 ± 2.6 μM) cell lines; hence has the potential to be further studied as anticancer agent. These compounds were also investigated for their ability to inhibit urease, β-glucuronidase, and phosphodiesterase enzymes. N-(2,6-Dimethylphenyl)-N′-(4′-nitrophenyl)urea (1) demonstrated 90 % inhibition of β-glucuronidase enzyme (IC50 ± SEM: 3.38 ± 0.043 μM).
1,3-disubstituted ureas as antiglycating agents
Perveen, Shahnaz,Mustafa, Sana,Khan, Khalid Mohammed,Choudhary, Muhammad Iqbal
, p. 1603 - 1611 (2014/03/21)
Twenty one (21) 1,3-disubstituted urea derivatives were screened for their antiglycating potential and some of them displayed promising activity. Compound N-butyl-N'-(4-nitrophenyl)urea (6) and Nisopropyl-N'-(4-nitrophenyl)urea (18) exhibited excellent activity and could be investigated in search of medicines treating diabetes and associated complications.
Substituted urea derivatives: A potent class of antidepressant agents
Perveen, Shahnaz,Mustafa, Sana,Khan, Muhammad A.,Dar, Ahsana,Khan, Khalid M.,Voelter, Wolfgang
experimental part, p. 330 - 336 (2012/08/28)
A series of fourteen (14) N-nitrophenyl-N'-(alkyl/aryl)urea and symmetrical 1,3-disubstituted urea derivatives were synthesized and evaluated for their antidepressant activity in mice. Among them, N-(4-nitrophenyl)-N'-(1'- phenylethyl)urea (1), demonstrat
N-phenyl-N'-pyridinylureas as anticonvulsant agents
Pavia,Lobbestael,Taylor,Hershenson,Miskell
, p. 854 - 861 (2007/10/02)
A series of N-phenyl-N'-pyridinylureas was examined for anticonvulsant activity. Extensive structure/activity investigations revealed optimal activity in the N-(2,6-disubstituted-phenyl)-N'-(4-pyridinyl)urea series, with 37 exhibiting the best overall anticonvulsant profile. Compound 37 was effective against seizures induced by maximal electroshock but did not protect mice from clonic seizures produced by the convulsant pentylenetetrazol. The overall pharmacological profile suggests that 37 would be of therapeutic use in the treatment of generalized tonic-clonic and partial seizures. Compound 37 was selected for Phase 1 clinical trials.
