1087349-71-0Relevant academic research and scientific papers
Chiral Phosphine–Phosphite Ligands in Asymmetric Gold Catalysis: Highly Enantioselective Synthesis of Furo[3,4-d]-Tetrahydropyridazine Derivatives through [3+3]-Cycloaddition
Du, Qingwei,Neud?rfl, J?rg-Martin,Schmalz, Hans-Günther
supporting information, p. 2379 - 2383 (2018/01/27)
The AuI-catalyzed reaction of 2-(1-alkynyl)-2-alken-1-ones with azomethine imines regio- and diastereoselectively affords furo[3,4-d]tetrahydropyridazines in a tandem cyclization/intermolecular [3+3]-cycloaddition process under mild conditions.
Asymmetrie hydroformylation using Taddol-based chiral phosphine - Phosphite ligands
Robert, Tobias,Abiri, Zohar,Wassenaar, Jeroen,Sandee, Albertus J.,Romanski, Steffen,Neudoerfl, Joerg-Martin,Schmalz, Hans-Guenther,Reek, Joost N. H.
scheme or table, p. 478 - 483 (2010/04/01)
A small library of 17 modular and easily accessible phenol-derived chiral phosphine - phosphite ligands was evaluated in the asymmetric Rh-catalyzed hydroformylation of styrene. It was found that the stereochemical outcome of the reaction is highly dependent on the chiral phosphite moiety and the substituents on the phenolic backbone. Among the ligands studied, Taddol-based ligands of type 10 bearing bulky substituents in ortho-position to the phosphite performed best, with enantioselectivities of up to 85% ee and regioselectivities of ≥98:2. High-pressure NMR of the active catalyst [HRh(P-P)(CO)2] (P-P = 10h) revealed an equatorial-apical coordination of the ligand at rhodium. Temperature dependency of the coupling constants observed during the experiment indicates equilibrium between the two equatorial-apical isomers, with the isomer in which the phosphite occupies the equatorial position being the dominant species.
Modular synthesis of chiral phosphine-phosphite-ligands from phenolic precursors: A new approach to bidentate chelate ligands exploiting a P-O to P-C migration rearrangement
Velder, Janna,Robert, Tobias,Weidner, Ingo,Neudoerfl, Joerg-Martin,Lex, Johann,Schmalza, Hans-Guenther
supporting information; experimental part, p. 1309 - 1315 (2009/05/30)
An efficient and modular approach to bidentate phosphine-phosphite ligands formally derived from a 6-alkyl-2-phosphanylphenol, a chiral diol and phosphorus trichloride has been developed. In a key step, a borane-protected phosphinite, prepared from an o-b
