108770-97-4

Upstream product

• 7417-81-4 benzyl phenyl sulfoxide 
• 19524-06-2 4-bromopyridine hydrochloride 
• 5427-04-3 diphenylmethyl phenyl sufoxide 
• 1120-87-2 4-bromopyridin 
• 108-98-5 thiophenol 
• 33399-48-3 4-(phenylthio)pyridine 

Downstream Products

• 945-51-7 1,1'-sulfinylbisbenzene 
• 108771-03-5 furan-2-yl(pyridin-4-yl)methanol 
• 127411-04-5 4-Benzenesulfinyl-3-trimethylsilanyl-pyridine 
• 1620-30-0 diphenyl(pyridin-4-yl)methanol 
• 108771-04-6 1-Pyridin-4-yl-cyclohex-2-enol 
• 62113-27-3 1-pyridin-4-yl-cyclopent-2-enol 
• 108771-01-3 2-Phenyl-1-pyridin-4-yl-propan-1-ol 
• 108771-12-6 4-((S)-Toluene-4-sulfinyl)-pyridine 
• 81417-96-1 1-[4]Pyridyl-cyclohexanol 
• 581-47-5 4-(2-pyridyl)pyridine 
• 553-26-4 4,4'-bipyridine 
• 4394-11-0 3,4'-bipyridyl 
• 127411-05-6 (4-Benzenesulfinyl-pyridin-3-yl)-phenyl-methanol 
• 33974-27-5 phenyl(pyridin-4-yl)methanol 

Relevant academic research and scientific papers

Diaryl sulfoxides from aryl benzyl sulfoxides: A single palladium-catalyzed triple relay process

A novel approach to produce diaryl sulfoxides from aryl benzyl sulfoxides is reported. Optimization of the reaction conditions was performed using high-throughput experimentation techniques. The [Pd(dba)2]/NiXantPhos catalyst system successfully promotes a triple relay process involving sulfoxide α-arylation, C-S bond cleavage, and C-S bond formation. The byproduct benzophenone is formed by an additional palladium-catalyzed process. It is noteworthy that palladium-catalyzed benzylative C-S bond cleavage of sulfoxides is unprecedented. A wide range of aryl benzyl sulfoxides, as well as alkyl benzyl sulfoxides with various (hetero)aryl bromides were employed in the triple relay process in good to excellent yields (85-99 %). Moreover, aryl methyl sulfoxides, dibenzyl sulfoxides, and dimethylsulfoxide could be utilized to generate diaryl sulfoxides involving multiple catalytic cycles by a single catalyst. Three for one: The [Pd(dba)2]/NiXantPhos (dba=dibenzylideneacetone) catalyst system successfully promotes a triple relay process involving sulfoxide α-arylation, C-S bond cleavage, and C-S bond formation to give diaryl sulfoxides (see picture). Aryl benzyl sulfoxides, as well as alkyl benzyl sulfoxides reacted with various (hetero)aryl bromides. Copyright

2-pyridyl sulfoxide: A versatile and removable directing group for the PdII-catalyzed direct C-H olefination of arenes

Removable and versatile: The 2-pyridylsulfinyl group has proved to be an efficient directing group in the PdII-catalyzed aryl ortho C-H olefination. This catalyst system enables the sequential double olefination to give asymmetrically di-ortho-functionalized arenes. The sulfinyl directing group can be easily cleaved, providing access to 1,3-disubstituted arenes, or transformed into a thiol group.