19490-94-9

Usage

Structure

Combination of a phenyl group and a pyridinyl group attached to an ethanol molecule the compound is formed by linking these two functional groups to the ethanol backbone.

Physical state

Colorless or light yellow liquid at room temperature the compound appears as a liquid with a pale color when at room temperature.

Molecular weight

229.29 g/mol the mass of one mole of 1-Phenyl-1-(pyridin-4-yl)ethanol is 229.29 grams.

Pharmaceutical applications

Used as a starting material for the synthesis of various drugs and pharmaceutical products the compound serves as a base for creating a range of medications and health-related products.

Organic synthesis

Used as a reagent in organic synthesis 1-Phenyl-1-(pyridin-4-yl)ethanol helps facilitate chemical reactions in the creation of other organic compounds.

Building block

Utilized as a building block in the production of various chemical compounds the compound is an essential component in the synthesis of numerous other chemicals.

Upstream product

• 917-64-6 methyl magnesium iodide 
• 14548-46-0 4-Benzoylpyridine 
• 1122-54-9 methyl (4-pyridyl) ketone 
• 108-86-1 bromobenzene 
• 591-51-5 phenyllithium 
• 108770-97-4 4-pyridyl phenyl sulfoxide 
• 98-86-2 acetophenone 
• 100-48-1 pyridine-4-carbonitrile 
• 100-58-3 phenylmagnesium bromide 
• 626-61-9 4-Chloropyridine 
• 71-43-2 benzene 
• 42362-47-0 1-phenyl-1-(4-pyridyl)ethane 
• 2116-65-6 4-benzyl pyridine 

Downstream Products

• 54813-56-8 1-phenyl-1-(4-pyridyl)ethylene 
• 42362-47-0 1-phenyl-1-(4-pyridyl)ethane 
• 34361-25-6 1-methyl-4-(1-phenyl-ethyl)-1,2,3,6-tetrahydro-pyridine 

Relevant academic research and scientific papers

Reductive arylation of aliphatic and aromatic aldehydes with cyanoarenes by electrolysis for the synthesis of alcohols

An electroreductive arylation reaction of aliphatic and aromatic aldehydes as well as ketones with electro-deficient (hetero)arenes is described. A variety of cyano(hetero)arenes and carbonyl compounds, especially aliphatic aldehydes, have been examined, providing secondary and tertiary alcohols in moderate to good yields. Mechanistic studies, including cyclic voltammetry (CV), electron paramagnetic resonance (EPR), and divided-cell experiments, support the generation of aliphatic ketyl radicals and persistent heteroaryl radical anions via cathodic reduction followed by radical-radical cross-coupling.

Iron-catalysed 1,2-aryl migration of tertiary azides

1,2-Aryl migration of α,α-diaryl tertiary azides was achieved by using the catalytic system of FeCl2/N-heterocyclic carbene (NHC) SIPr·HCl. The reaction generated aniline products in good yields after one-pot reduction of the migration-resultant imines.

Metal-Free Synthesis of C-4 Substituted Pyridine Derivatives Using Pyridine-boryl Radicals via a Radical Addition/Coupling Mechanism: A Combined Computational and Experimental Study

Density functional theory investigations revealed that the pyridine-boryl radical generated in situ using 4-cyanopyridine and bis(pinacolato)diboron could be used as a bifunctional “reagent”, which serves as not only a pyridine precursor but also a boryl radical. With the unique reactivity of such radicals, 4-substituted pyridine derivatives could be synthesized using α,β-unsaturated ketones and 4-cyanopyridine via a novel radical addition/C-C coupling mechanism. Several controlled experiments were conducted to provide supportive evidence for the proposed mechanism. In addition to enones, the scope could be extended to a wide range of boryl radical acceptors, including various aldehydes and ketones, aryl imines and alkynones. Lastly, this transformation was applied in the late-stage modification of a complicated pharmaceutical molecule.

A succinic acid many west pulls sensitively impurity A preparation method (by machine translation)

The invention discloses a succinic acid many west pulls sensitively impurity A preparation method, relates to the technical field of chemical industry, comprising the following steps: to 4 - acetyl pyridine as raw material, addition reaction with the Grig

Iron-Catalyzed Aerobic Oxidation of (Alkyl)(aryl)azinylmethanes

An iron-catalyzed aerobic oxidation of (alkyl)(aryl)azinylmethanes has been developed leading to tertiary alcohols in moderate to good yields. Hock rearrangement was identified as a major side reaction leading to a complex mixture of undesired products. Addition of thiourea sometimes allows inhibiting this side reaction and steers the reaction towards the desired products.

Naphthalene-catalysed lithiation of chlorinated nitrogenated aromatic heterocycles and reaction with electrophiles

Naphthalene catalysed reductive lithiation of various chloroazines (1, 7, 10, 13) in the presence of different electrophiles yields, after hydrolysis, the expected functionalised heterocycles with one (2, 8), two (11, 14a-d) and three nitrogen atoms in the ring (14e,f). This methodology allowed us to trap in situ the lithium imine derived from the reaction of 2- pyridyllithium with benzonitrile, by reaction with a Grignard reagent in the presence of titanium alkoxides. 2,4-Dimethoxypyrimidines (14a,c,d) are demethylated under acidic conditions to give the corresponding uracil derivatives 16. (C) 2000 Elsevier Science Ltd.

Kinetics of the self-assembly of α-cyclodextrin [2]pseudorotaxanes with 1,12-bis(4-(α-alkyl-α-methylmethanol)pyridinium)dodecane dications in aqueous solution

The kinetics and thermodynamics of the self-assembly of a series of [2]pseudorotaxanes comprised of α-cyclodextrin (α-CD) and racemic 1,12- bis(4-(α-alkyl-α-methylmethanol)pyridinium)dodecane dications (L(CH2)12L2+) in aqueous solutions have been investigated using 1H NMR spectroscopy. The mechanism of assembly involves inclusion of the α-methyl- α-alkylmethanol substituent groups (-C(CH3)(OH)R, where R = Me, Et, Pr, Bu, allyl, and 4-butenyl) by α-CD, followed by a rate-determining passage of the cyclodextrin over the pyridinium group onto the dodecamethylene chain. Dicationic threads containing end groups with R = Ph or i-Pr or where L = 4- (α,α-diethylmethanol)-pyridinium did not form α-cyclodextrin pseudorotaxanes, even after prolonged heating. The trends in the rate and activation parameters may be related to the size, shape, and hydrophobicity of the alkyl substituents and are compared with several other systems from the literature. An increase in the length and hydrophobicity of the alkyl group increases the strength of end group inclusion and decreases the rate of threading. In addition, the presence of unsaturation in the alkyl substituent (allyl vs propyl and 4-butenyl vs butyl) results in an increase in the threading rate constant.

A novel hydroxyalkyl-decyanation of 4-pyridinecarbonitrile: A facile selective synthesis of 4-pyridinemethanols

Reactions of 4-pyridinecarbonitrile with alkali metal and ketones or aldehydes provide a convenient and useful method for synthesis of 4-pyridinemethanols in good yields.

Flexible N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine analogues: Synthesis and monoamine oxidase catalyzed bioactivation

Eighteen analogues of N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) were synthesized and evaluated as substrates of monoamine oxidase. In general, the flexible analogues, characterized by the presence of a methylene (or ethylene) bridge between the aryl/heteroaryl and tetrahydropyridyl moieties, were better substrates of the enzyme than the conformationally restricted MPTP. It is suggested that the increased oxidative activity of these flexible analogues reflects enhanced binding due to the ability of the C-4-aryl/heteroaryl substituent to gain access to a hydrophobic pocket within the substrate binding site.

REACTIONS OF PYRIDYL AND QUINOLYL SULFOXIDES WITH GRIGNARD REAGENT : A CONVENIENT PREPARATION OF PYRIDYL AND QUINOLYL GRIGNARD REAGENTS

3-,4-Pyridyl and 4-quinolyl Grignard reagents were generated by the reaction of the corresponding phenyl sulfoxides with PhMgBr and give the adducts upon treatment with various aldehydes and ketones.The stereochemistry for the reaction was investigated.