108771-05-7Relevant academic research and scientific papers
Electrochemical Ammonium Cation-Assisted Hydropyridylation of Ketone-Activated Alkenes: Experimental and Computational Mechanistic Studies
Li, Bingwen,Ma, Jing,Tian, Laijin,Wen, Jiangwei,Yan, Kelu,Yang, Jianjing
supporting information, (2022/01/08)
This work describes an electrochemical ammonium cation enabled hydropyridylation of ketone-activated alkenes under metal- and exogenous reductant free conditions giving access to β-pyridyl ketones, through dual proton-coupled electron transfer and radical cross-coupling. It features a broad substrate scope and allows a gram-scale synthesis. Ammonium chloride plays various roles in this transformation such as the hydrogen donor, the protonation reagent, and electrolyte. In particular, various experiments and density functional theory (DFT) calculation results show the mechanism of dual proton-coupled electron transfer followed by radical cross-coupling is the preferred pathway. (Figure presented.).
PREPARATION OF PYRIDYL GRIGNARD REAGENTS AND CROSS COUPLING REACTIONS WITH SULFOXIDES BEARING AZAHETEROCYCLES
Furukawa, Naomichi,Shibutani, Tadao,Fujihara, Hisashi
, p. 5845 - 5848 (2007/10/02)
Pyridyl Grignard reagents were prepared from the corresponding iodopyridine and EtMgBr.New cross coupling reactions of the Grignard reagents with azaheterocycles took place on the sulfinyl sulfur atom to afford biazaheteroaryls.
REACTIONS OF PYRIDYL AND QUINOLYL SULFOXIDES WITH GRIGNARD REAGENT : A CONVENIENT PREPARATION OF PYRIDYL AND QUINOLYL GRIGNARD REAGENTS
Furukawa, Naomichi,Shibutani, Tadao,Matsumura, Kazunori,Fujihara, Hisashi,Oae, Shigeru
, p. 3899 - 3902 (2007/10/02)
3-,4-Pyridyl and 4-quinolyl Grignard reagents were generated by the reaction of the corresponding phenyl sulfoxides with PhMgBr and give the adducts upon treatment with various aldehydes and ketones.The stereochemistry for the reaction was investigated.
