108774-33-0Relevant academic research and scientific papers
Scalable and Highly Diastereo- and Enantioselective Catalytic Diels-Alder Reaction of α,β-Unsaturated Methyl Esters
Gatzenmeier, Tim,Turberg, Mathias,Yepes, Diana,Xie, Youwei,Neese, Frank,Bistoni, Giovanni,List, Benjamin
supporting information, p. 12671 - 12676 (2018/10/15)
Despite tremendous advances in enantioselective catalysis of the Diels-Alder reaction, the use of simple α,β-unsaturated esters, one of the most abundant and useful class of dienophiles, is still severely limited in scope due to their low reactivity. We report here a catalytic asymmetric Diels-Alder methodology for a large variety of α,β-unsaturated methyl esters and different dienes based on extremely reactive silylium imidodiphosphorimidate (IDPi) Lewis acids. Mechanistic insights from accurate domain-based local pair natural orbital coupled-cluster (DLPNO-CCSD(T)) calculations rationalize the catalyst control and stereochemical outcome.
[3+2] and [4+1] cycloaddition reactions of fischer alkoxy(alkenyl)carbene complexes with electronically neutral 1,3-dienes
Barluenga, Jose,Lopez, Salome,Florez, Josefa
, p. 231 - 233 (2007/10/03)
Regio- and stereochemically controlled formation of cyclopentenes has been achieved through the reaction of transition-metal-alkoxy(alkenyl)carbene complexes and neutral 1,3-dienes (see scheme; BHT=2,6-di-tert-butyl-4-methylphenol). Reaction conditions di
