1087784-78-8

Basic information

• Product Name: tert-butyl 1-(hydroxymethyl)-3-azabicyclo[3.1.1]heptane-3-carboxylate
• Synonyms: tert-butyl 1-(hydroxymethyl)-3-azabicyclo[3.1.1]heptane-3-carboxylate
• CAS NO: 1087784-78-8
• Molecular Formula: C12H21NO3
• Molecular Weight: 227.30004
• Mol File: 1087784-78-8.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• CAS DataBase Reference: tert-butyl 1-(hydroxymethyl)-3-azabicyclo[3.1.1]heptane-3-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-butyl 1-(hydroxymethyl)-3-azabicyclo[3.1.1]heptane-3-carboxylate(1087784-78-8)
• EPA Substance Registry System: tert-butyl 1-(hydroxymethyl)-3-azabicyclo[3.1.1]heptane-3-carboxylate(1087784-78-8)

Safety Data

• Hazardous Substances Data: 1087784-78-8(Hazardous Substances Data)

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 1628783-91-4 methyl 2-oxo-3-azabicyclo[3.1.1]heptane-1-carboxylate 
• 1628783-89-0 diisopropyl 3-(((tert-butoxycarbonyl)amino)methyl)cyclobutane-1,1-dicarboxylate 
• 1628783-90-3 (3,3-bis(isopropoxycarbonyl)cyclobutyl)acetic acid 
• 1628783-88-9 diisopropyl 3-((hydrazinecarbonyl)methyl)cyclobutane-1,1-dicarboxylate 
• 1172693-01-4 C₇H₁₃NO 
• 1628783-87-8 diisopropyl 3-((methoxycarbonyl)methyl)cyclobutane-1,1-dicarboxylate 
• 1628783-86-7 diisopropyl 3-((methoxycarbonyl)methylidene)cyclobutane-1,1-dicarboxylate 
• 893724-10-2 dipropan-2-yl 3-oxocyclobutane-1,1-dicarboxylate 
• 115118-68-8 3,3-dimethoxycyclobutane-1,1-dicarboxylic acid diisopropyl ester 

Downstream Products

• 1640998-93-1 C₁₂H₁₉NO₃ 
• 1000931-22-5 3-(tert-butoxycarbonyl)-3-azabicyclo[3.1.1]heptane-1-carboxylic acid 

Relevant articles and documents

Intramolecular functional group differentiation as a strategy for the synthesis of bridged bicyclic β-amino acids

Differentiation of identical electrophilic functional groups (carboxylates) by a strategically placed internal nucleophile (an amino group) in cyclic precursors was used as a key general approach to functionalized azabicyclic scaffolds. The utility of the method was demonstrated by the synthesis of three bicyclic β-amino acids (analogues of nipecotic acid), which were prepared in good yields and on a relatively large scale.