893724-10-2

Basic information

• Product Name: 3-Oxo-cyclobutane-1,1-dic...
• Synonyms: 3-Oxo-cyclobutane-1,1-dic...;3-Oxo-cyclobutane-1,1-dicarboxylic acid diisopropyl ester;1,1-bis(propan-2-yl) 3-oxocyclobutane-1,1-dicarboxylate;Diisopropyl 3-oxocyclobutane-1,1-dicarboxylate
• CAS NO: 893724-10-2
• Molecular Formula: C₁₂H₁₈O₅
• Molecular Weight: 242.26832
• Mol File: 893724-10-2.mol

Chemical Properties

• Boiling Point: 293.2±40.0 °C(Predicted)
• Appearance: /
• Density: 1.165±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 3-Oxo-cyclobutane-1,1-dic...(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Oxo-cyclobutane-1,1-dic...(893724-10-2)
• EPA Substance Registry System: 3-Oxo-cyclobutane-1,1-dic...(893724-10-2)

Safety Data

• Hazardous Substances Data: 893724-10-2(Hazardous Substances Data)

Usage

Uses

Used in Polymer Synthesis:
3-Oxo-cyclobutane-1,1-dicarboxylic acid is used as a monomer or building block for the synthesis of polymers. Its unique structure and properties make it a promising candidate for the development of new materials with specific characteristics.
Used in Chemical Reactions:
As a 3-oxo compound, 3-Oxo-cyclobutane-1,1-dicarboxylic acid holds potential to participate in multiple chemical reactions, which could lead to the discovery of new compounds and applications in various fields. However, further research is needed to explore its full potential and understand its reactivity and behavior in different chemical environments.
Note: Since the specific applications, safety, toxicity, or ecological impact of 3-Oxo-cyclobutane-1,1-dicarboxylic acid are not yet fully explored or documented, it is essential to conduct thorough studies and assessments before implementing it in any industrial or commercial applications.

Upstream product

• 115118-68-8 3,3-dimethoxycyclobutane-1,1-dicarboxylic acid diisopropyl ester 
• 869109-31-9 dipropan-2-yl 3-hydroxycyclobutane-1,1-dicarboxylate 
• 869109-30-8 dipropan-2-yl 3-(benzyloxy)cyclobutane-1,1-dicarboxylate 
• 13195-64-7 diisopropyl malonate 

Downstream Products

• 1640998-93-1 C₁₂H₁₉NO₃ 
• 1628783-91-4 methyl 2-oxo-3-azabicyclo[3.1.1]heptane-1-carboxylate 
• 1087784-78-8 tert-butyl 1-(hydroxymethyl)-3-azabicyclo[3.1.1]heptane-3-carboxylate 
• 1000931-22-5 3-(tert-butoxycarbonyl)-3-azabicyclo[3.1.1]heptane-1-carboxylic acid 
• 1403767-29-2 diisopropyl 3-fluorocyclobutane-1,1-dicarboxylate 
• 869109-31-9 dipropan-2-yl 3-hydroxycyclobutane-1,1-dicarboxylate 

Relevant articles and documents

Intramolecular functional group differentiation as a strategy for the synthesis of bridged bicyclic β-amino acids

Differentiation of identical electrophilic functional groups (carboxylates) by a strategically placed internal nucleophile (an amino group) in cyclic precursors was used as a key general approach to functionalized azabicyclic scaffolds. The utility of the method was demonstrated by the synthesis of three bicyclic β-amino acids (analogues of nipecotic acid), which were prepared in good yields and on a relatively large scale.

SPIROCYCLIC HAT INHIBITORS AND METHODS FOR THEIR USE

Compounds having a structure of Formula (IX) or a stereoisomer, tautomer or pharmaceutically acceptable salt thereof, wherein R1, R2a, R2b, R3a, R3b, R4a, R4b, Q1----Q2, R6, R7, A, B, W, x, and y are as defined herein and are provided. Pharmaceutical compositions comprising such compounds and methods for treating various HAT-related conditions or diseases, including cancer, by administration of such compounds are also provided.

COMBINATIONS OF HEPATITIS C VIRUS INHIBITORS

The present disclosure is generally directed to antiviral compounds, and more specifically directed to combinations of compounds which can inhibit the function of the NS5A protein encoded by Hepatitis C virus (HCV), compositions comprising such combinations, and methods for inhibiting the function of the NS5A protein.

NOVEL AZA-OXO-INDOLES FOR THE TREATMENT AND PROPHYLAXIS OF RESPIRATORY SYNCYTIAL VIRUS INFECTION

The invention provides novel compounds having the general formula:(I) wherein R1, R2, R3, R4, W and X are as described herein, compositions including the compounds and methods of using the compounds.

Gram-scale synthesis of 3,5-methanonipecotic acid, a nonchiral bicyclic β-amino acid

A scalable synthesis was developed of 3,5-methanoni?pecotic acid (3-azabicyclo[3.1.1]heptane-1-carboxylic acid), a rare example of a conformationally constrained nonchiral β-amino acid, potentially useful in peptide engineering and peptidomimetic drug design. A retrosynthetic strategy based on disconnections exclusively within the symmetry planes of the target and the intermediate molecules was found to be useful and might deliver expedite syntheses in other similar cases. Georg Thieme Verlag Stuttgart New York.

Trifluoromethyl-substituted analogues of 1-aminocyclobutane-1-carboxylic acid

Trifluoromethyl-substituted analogues of the 1-amino-cyclobutane-1- carboxylic acid - 1-amino-3-(trifluoromethyl) cyclobutanecarboxylic and 1-amino-3,3-bis(trifluoromethyl)cyclobutane-carboxylic acids - have been synthesized from 1,3-dibromoacetone dimethyl ketal. The key step of the syntheses is a transformation of the acid moiety into the trifluoromethyl group using SF4 and HF. Georg Thieme Verlag Stuttgart.

AZETIDINE AND CYCLOBUTANE DERIVATIVES AS JAK INHIBITORS

The present invention relates to azetidine and cyclobutane derivatives, as well as their compositions, methods of use, and processes for preparation, which are JAK inhibitors useful in the treatment of JAK-associated diseases including, for example, inflammatory and autoimmune disorders, as well as cancer.