1087789-01-2

Upstream product

• 862129-72-4 4-(methylsulfonyl)cyclohexan-1-one 
• 75-86-5 2-hydroxy-2-methylpropanenitrile 
• 100-46-9 benzylamine 
• 78847-53-7 4-oxocyclohexyl methanesulfonate 

Downstream Products

• 1193090-81-1 (7-benzyl-7-azabicyclo[2.2.1]hept-1-yl)-pyridin-3-yl-methanone 
• 1193090-77-5 7-benzyl-7-azabicyclo[2.2.1]heptane-1-carbaldehyde 
• 1193090-83-3 C-(7-benzyl-7-azabicyclo[2.2.1]hept-1-yl)-methylamine 
• 1193090-79-7 (7-benzyl-7-azabicyclo[2.2.1]hept-1-yl)-(6-chloro-pyridin-3-yl)-methanone 

Relevant academic research and scientific papers

A straightforward entry to 7-azabicyclo[2.2.1]heptane-l-carbonitriles in the synthesis of novel epibatidine analogues

This paper presents the synthesis of epibatidine analogues by a straightforward one-pot method for the synthesis of 7azabicyclo[2.2.1]heptane-1- carbonitriles, starting from cyclohexanones bearing a leaving group at the 4-position. In situ imine formation

STRAIGHTFORWARD ENTRY TO 7-AZABICYCLO[2.2.1]HEPTANE-1-CARBONITRILES AND SUBSEQUENT SYNTHESIS OF EPIBATIDINE ANALOGUES

The present invention relates to a group of substituted-7-azabicyclo-[2.2.1]heptyl derivatives with biological activity. The present invention also relates to synthetic methods for producing said substituted-7-azabicyclo-[2.2.1]heptyl derivatives. The present invention also relates to certain intermediates for producing such substituted-7-azabicyclo-[2.2.1]heptyl derivatives, as well as a synthetic method for producing such intermediates. The present invention also relates to pharmaceutical compositions comprising such substituted-7-azabicyclo-[2.2.1]heptyl derivatives, as well as their use as medicaments for the treatment of diseases mediated by a Nicotinic Acetylcholine Receptor or a receptor being a member of the Neurotransmitter-gated Ion Channel Superfamily, such as pain, Alzheimer's disease, Parkinson's disease, schizophrenia, epilepsy and nicotine addiction.