862129-72-4

Basic information

• Product Name: 4-(Methylsulfonyl)cyclohexanone
• Synonyms: 4-(Methylsulfonyl)cyclohexanone;4-Methanesulfonyl-cyclohexanone;4-(Methylsulfonyl)cyclohexan-1-one
• CAS NO: 862129-72-4
• Molecular Formula: C₇H₁₂O₃S
• Molecular Weight: 176.23338
• Mol File: 862129-72-4.mol
• Article Data: 10

Chemical Properties

• Appearance: /
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 4-(Methylsulfonyl)cyclohexanone(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(Methylsulfonyl)cyclohexanone(862129-72-4)
• EPA Substance Registry System: 4-(Methylsulfonyl)cyclohexanone(862129-72-4)

Safety Data

• Hazardous Substances Data: 862129-72-4(Hazardous Substances Data)

Usage

Uses

4-Methylsulfonylcyclohexanone is a reactant used in the preparation of piperidine derivatives as selective estrogen receptor modulators (SERMs) for the potential treatment of uterine fibroids.

Upstream product

• 23510-98-7 4-(methylthio)cyclohexan-1-one 
• 141120-33-4 8-methylsulfonyloxy-1,4-dioxaspiro[4.5]decane 
• 4746-97-8 cyclohexanedione monoethylene ketal 
• 38053-91-7 2-trimethylsilyloxy-1,3-butadiene 
• 3680-02-2 methyl ethenyl sulphone 
• 55103-51-0 8-(methylthio)-1,4-dioxaspiro[4.5]decane 
• 23511-05-9 toluene-4-sulfonic acid 1,4-dioxa-spiro[4.5]dec-8-yl ester 
• 22428-87-1 4,4-ethylenedioxycyclohexan-1-ol 

Downstream Products

• 862129-73-5 (+/-)-trifluoro-methanesulfonic acid 4-methanesulfonyl-cyclohex-1-enyl ester 
• 1087789-01-2 7-benzyl-7-azabicyclo[2.2.1]heptane-1-carbonitrile 

Relevant articles and documents

PYRIDINYL PYRAZOLES AS MODULATORS OF RORyT

The present invention comprises compounds of Formula I. wherein: R1, R3, R4, R5, R6, and Q are defined in the specification. The invention also comprises a method of treating or ameliorating a ROR-γ-t mediated syndrome, disorder or disease, including wherein the syndrome, disorder or disease is selected from the group consisting of rheumatoid arthritis, psoriatic arthritis, and psoriasis. The invention also comprises a method of modulating RORγt activity in a mammal by administration of a therapeutically effective amount of at least one compound of Formula I.

6-AMINOPYRIDIN-3-YL PYRAZOLES AS MODULATORS OF RORgT

The present invention comprises compounds of Formula I. wherein: R1, Q, R3, R4, R5, R6, A1, and A2 are defined in the specification. The invention also comprises a method of treating or ameliorating a ROR-γ-t mediated syndrome, disorder or disease, including wherein the syndrome, disorder or disease is selected from the group consisting of rheumatoid arthritis, psoriatic arthritis, and psoriasis. The invention also comprises a method of modulating RORγt activity in a mammal by administration of a therapeutically effective amount of at least one compound of Formula I.

SUBSTITUTED 5-CYANOINDOLE COMPOUNDS AND USES THEREOF

A compound of Formula (I), or a pharmaceutically acceptable salt thereof, is provided that has been shown to be useful for the treatment of lysine (K)-specific demethylase 1A (LSD1) - mediated diseases or disorders, Formula (I), wherein R1, R2, R3, R4, and R5 are as defined herein.