108783-63-7Relevant academic research and scientific papers
Discovery of an in Vivo Tool to Establish Proof-of-Concept for MAP4K4-Based Antidiabetic Treatment
Ammirati, Mark,Bagley, Scott W.,Bhattacharya, Samit K.,Buckbinder, Leonard,Carlo, Anthony A.,Conrad, Rebecca,Cortes, Christian,Dow, Robert L.,Dowling, Matthew S.,El-Kattan, Ayman,Ford, Kristen,Guimar?es, Cristiano R. W.,Hepworth, David,Jiao, Wenhua,Laperle, Jennifer,Liu, Shenping,Londregan, Allyn,Loria, Paula M.,Mathiowetz, Alan M.,Munchhof, Michael,Orr, Suvi T. M.,Petersen, Donna N.,Price, David A.,Skoura, Athanasia,Smith, Aaron C.,Wang, Jian
supporting information, p. 1128 - 1133 (2015/11/24)
Recent studies in adipose tissue, pancreas, muscle, and macrophages suggest that MAP4K4, a serine/threonine protein kinase may be a viable target for antidiabetic drugs. As part of the evaluation of MAP4K4 as a novel antidiabetic target, a tool compound,
Retinoid-related receptor function regulating agent
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, (2008/06/13)
1,3-Azole derivatives, pharmaceutical compositions thereof and methods for regulating the function of retinoid-related receptors with 1,3-azole derivatives are disclosed. Such regulation may be useful for preventing or treating diabetes, preventing or treating hyperlipidemia, preventing or treating impaired glucose tolerance (IGT) or for preventing transition from impaired glucose tolerance to diabetes.
SYNTHESIS AND SPECTRAL AND LUMINESCENT PROPERTIES OF 4-(5-ARYLOXAZOYL-2)BENZOIC ACIDS AND THEIR DERIVATIVES
Krasovitskii, B. M.,Shershukov, V. M.,Volkov, V. L.
, p. 1022 - 1025 (2007/10/02)
Condensation of acid chloride of monomethyl terephtalate with ω-aminomethylarylketones and subsequent cyclodehydration of the resulting amides in sulfuric acid or phosphorus oxychloride give rise to methyl 4-(5-aryloxazolyl-2)benzoates which led to the co
