1088496-47-2Relevant academic research and scientific papers
Optimization and structure-activity relationship of a series of 1-phenyl-1,8-naphthyridin-4-one-3-carboxamides: Identification of MK-0873, a potent and effective PDE4 inhibitor
Guay, Daniel,Boulet, Louise,Friesen, Richard W.,Girard, Mario,Hamel, Pierre,Huang, Zheng,Laliberte, France,Laliberte, Sebastien,Mancini, Joseph A.,Muise, Eric,Pon, Doug,Styhler, Angela
, p. 5554 - 5558 (2008)
A SAR study of a series of 1-phenyl-1,8-naphthyridin-4-one-3-carboxamides is described. Optimization of the series was based on in vitro potency against PDE4, inhibition of the LPS-induced production of TNF-α in human whole blood and minimizing affinity f
