1088705-53-6

Basic information

• Product Name: N-[(1R,2R)-2-aMino-1,2-diphenylethyl]-N'-[3,5-bis(trifluoroMethyl)phenyl]-Thiourea
• Synonyms: N-[(1R,2R)-2-aMino-1,2-diphenylethyl]-N'-[3,5-bis(trifluoroMethyl)phenyl]-Thiourea
• CAS NO: 1088705-53-6
• Molecular Formula: C₂₃H₁₉F₆N₃S
• Molecular Weight: 483.4724792
• Mol File: 1088705-53-6.mol
• Article Data: 6

Chemical Properties

• Melting Point: 91-93 °C
• Boiling Point: 487.6±55.0 °C(Predicted)
• Appearance: /
• Density: 1.384±0.06 g/cm3(Predicted)
• PKA: 11.51±0.70(Predicted)
• CAS DataBase Reference: N-[(1R,2R)-2-aMino-1,2-diphenylethyl]-N'-[3,5-bis(trifluoroMethyl)phenyl]-Thiourea(CAS DataBase Reference)
• NIST Chemistry Reference: N-[(1R,2R)-2-aMino-1,2-diphenylethyl]-N'-[3,5-bis(trifluoroMethyl)phenyl]-Thiourea(1088705-53-6)
• EPA Substance Registry System: N-[(1R,2R)-2-aMino-1,2-diphenylethyl]-N'-[3,5-bis(trifluoroMethyl)phenyl]-Thiourea(1088705-53-6)

Safety Data

• Hazardous Substances Data: 1088705-53-6(Hazardous Substances Data)

Usage

General Description

N-[(1R,2R)-2-amino-1,2-diphenylethyl]-N'-[3,5-bis(trifluoromethyl)phenyl]-thiourea is a chemical compound with potential biological and pharmacological activities. It is a thiourea derivative with a molecular formula of C23H20F6N2S and a molecular weight of 482.47 g/mol. The compound has been studied for its potential as an anti-tumor, anti-inflammatory, and antioxidant agent. It has also shown promising results in inhibiting the growth of certain cancer cells. The compound's chemical structure and properties make it a promising candidate for further research and potential therapeutic applications.

Upstream product

• 23165-29-9 3,5-bistrifluoromethylphenylisothiocyanate 
• 35132-20-8 (R,R)-1,2-diphenylethylenediamine 

Downstream Products

• 1279128-92-5 (S)-tert-butyl-2-[(1R,2R)-2-{3-[3,5-bis(trifluoromethyl)phenyl]thioureido}-1,2-diphenylethylcarbamoyl]pyrrolidine-1-carboxylate 
• 1416912-94-1 C₃₀H₂₇F₆N₃S 
• 1416912-95-2 C₃₀H₂₇F₆N₃S 
• 1088705-62-7 C₃₀H₃₁F₆N₃S 
• 1088705-63-8 C₂₇H₂₇F₆N₃S 
• 1088705-57-0 C₃₁H₂₄F₉N₃S 

Relevant articles and documents

Novel synthesis method of oseltamivir

The invention provides a novel synthesis method of oseltamivir. The synthesis method comprises the following steps: taking a compound (E)-2-(2-nitrovinyl) isoindoline-1,3-diketone and ethyl pyruvate as initial raw materials, and carrying out Michael addition reaction under the condition of catalysis of a thiourea catalyst to obtain a corresponding Michael addition product; then, subjecting the Michael addition product and (formyl methylene) triphenyl phosphine to a Wittig reaction and a Henry reaction in a pot so as to obtain a ring closing product; and forming an etherified product from the ring closing product and a trichloroacetonitrile intermediate, and performing reduction, acetylation and de-protection to obtain oseltamivir. The reaction route comprises six steps, raw materials used in each step of reaction are easy to obtain and not expensive, the operation is easy, the yield of each step of reaction is high, no heavy metal or azide is used in the whole synthesis process, and the method is green and safe and can be applied to industrial production.

A highly efficient asymmetric Michael addition of α,α- disubstituted aldehydes to maleimides catalyzed by primary amine thiourea salt

The first highly efficient Michael addition of challenging α,α-disubstituted aldehydes to maleimides catalyzed by a simple bifunctional primary amine thiourea catalyst/benzoic acid system has been successfully developed to generate quaternary carbon cente

Highly effective and enantioselective α-amination of aldehydes promoted by chiral proline amide-thiourea bifunctional catalysts

A series of secondary amine-thiourea catalysts derived from l-proline and chiral diamine were prepared and first applied to highly enantioselective amination of unmodified aldehydes with various azodicarboxylates in excellent yields (up to 99%) and enanti