108893-60-3

Upstream product

• 4835-96-5 (-)-menthyl acrylate 
• 75-07-0 acetaldehyde 

Downstream Products

• 108893-64-7 (2R,3R)-3-Hydroxy-2-methyl-butyric acid (1S,2S,5R)-2-isopropyl-5-methyl-cyclohexyl ester 
• 108893-64-7 (2S,3S)-3-Hydroxy-2-methyl-butyric acid (1S,2S,5R)-2-isopropyl-5-methyl-cyclohexyl ester 
• 108893-64-7 (2R,3R)-3-Hydroxy-2-methyl-butyric acid (1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl ester 
• 108945-24-0 (2S,3S)-3-Hydroxy-2-methyl-butyric acid (1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl ester 

Relevant academic research and scientific papers

First Enantioselective Synthesis of Mikanecic Acid via Diels-Alder Cycloaddition Mediated Construction of Chiral Vinylic Quaternary Center

Chiral mikanecic acid (1) was synthesized in 74 percent enantiomeric purity (92 percent ee after crystallization) via asymmetric Diels-Alder reaction of a novel in situ generated chiral 1,3-butadiene-2-carboxylate (A).

Chiral acrylates as substrates in Baylis-Hillman reaction

DABCO induces diastereoselective (7-70%) coupling of chiral acrylates (1-3) with aldehydes to produce the corresponding 2-(1-hydroxyalkyl)acrylates.

FACTORS AFFECTING STEREOCHEMICAL CONTROL IN DIRECTED HOMOGENEOUS HYDROGENATION OF α-HYDROXYALKYLARCYLATES

The degree of asymmetric induction observed in hydrogenation of menthyl 3-hydroxy-2-methylenebutyrates catalysed by DIPAMP-Rh+ complexes is strongly dependent on anti-reduction product is formed with high enantioselection.