108908-74-3Relevant academic research and scientific papers
Preparation of 4-Unsubstituted β-Lactams from 4-Acetoxyazetidin-2-ones.A Formal Approach to Monobactams and Nocardicins
Arrieta, Ana,Lecea, Begona,Cossio, Fernando P.,Palomo, Claudio
, p. 3784 - 3791 (2007/10/02)
The synthesis of 4-unsubstituted azetidin-2-ones is described.Treatment of Schiff bases derived from α-methylcinnamaldehyde and amines with acetic acids in the presence of phenyl dichlorophosphate and triethylamine followed by ozonolysis of the resulting
N,N-DIMETHYLPHOSPHORAMIDIC DICHLORIDE: A CONVENIENT REAGENT FOR THE PREPARATION OF β-LACTAMS FROM ACETIC ACIDS AND IMINES
Cossio, Fernando P.,Ganboa, Inaki,Garcia, Jesus M.,Lecea, Begona,Palomo, C.
, p. 1945 - 1948 (2007/10/02)
A convenient reagent for the preparation of β-lactams from acetic acids and imines is described.A new route to α-keto-β-lactams from 3-bis(ethylthio)β-lactams is also reported.Reaction of 4-acethyl-β-lactams with diazomethane is also made.
NEW STEREOCHEMECAL OUTCOMES IN THE CYCLOADDITION OF ACID HALIDES OR EQUIVALENTS TO CINNAMYLIDENEAMINES: A CONCISE NEW APPROACH TO 4-ACETOXYAZETIDIN-2-ONES.
Aizpurua, J. M.,Cossio, F. P.,Lecea, B.,Palomo, C.
, p. 4359 - 4362 (2007/10/02)
The reaction between 2-methylcinnamylideneamines and acid halides or equivalents leads to the stereospecific formation of cis-β-lactams.A new three steps approach to 4-acetoxyazetidin-2-ones as building blocks of β-lactam antibiotics is also described
