108908-73-2

Upstream product

• 616-34-2 methoxycarbonylmethylamine 
• 15174-47-7 α-methyl-trans-cinnamaldehyde 
• 5680-79-5 glycine ethyl ester hydrochloride 

Downstream Products

• 108908-74-3 cis-1-((methoxycarbonyl)methyl)-4-(α-methylstyryl)-3-phthalimido-2-azetidinone 
• 108908-76-5 [(2R,3S)-2-((E)-1-Methyl-2-phenyl-vinyl)-4-oxo-3-phenoxy-azetidin-1-yl]-acetic acid methyl ester 
• 108908-77-6 ((2R,3S)-2-Acetyl-4-oxo-3-phenoxy-azetidin-1-yl)-acetic acid methyl ester 
• 108908-77-6 cis-4-acetyl-1-((methoxycarbonyl)methyl)-3-phenoxy-2-azetidinone 

Relevant academic research and scientific papers

Preparation of 4-Unsubstituted β-Lactams from 4-Acetoxyazetidin-2-ones.A Formal Approach to Monobactams and Nocardicins

The synthesis of 4-unsubstituted azetidin-2-ones is described.Treatment of Schiff bases derived from α-methylcinnamaldehyde and amines with acetic acids in the presence of phenyl dichlorophosphate and triethylamine followed by ozonolysis of the resulting

NEW STEREOCHEMECAL OUTCOMES IN THE CYCLOADDITION OF ACID HALIDES OR EQUIVALENTS TO CINNAMYLIDENEAMINES: A CONCISE NEW APPROACH TO 4-ACETOXYAZETIDIN-2-ONES.

The reaction between 2-methylcinnamylideneamines and acid halides or equivalents leads to the stereospecific formation of cis-β-lactams.A new three steps approach to 4-acetoxyazetidin-2-ones as building blocks of β-lactam antibiotics is also described