108912-14-7 Usage
Class
Propionic acid derivative
Use
Building block in pharmaceuticals and agrochemicals
Molecular weight
242.33 g/mol
Physical state
White to off-white solid
Solubility
Sparingly soluble in water, soluble in most organic solvents
Potential applications
Pharmaceuticals industry due to unique chemical structure and biological activity
Check Digit Verification of cas no
The CAS Registry Mumber 108912-14-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,0,8,9,1 and 2 respectively; the second part has 2 digits, 1 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 108912-14:
(8*1)+(7*0)+(6*8)+(5*9)+(4*1)+(3*2)+(2*1)+(1*4)=117
117 % 10 = 7
So 108912-14-7 is a valid CAS Registry Number.
108912-14-7Relevant articles and documents
Synthesis and evaluation of S-4-(3-thienyl)phenyl-α-methylacetic acid
Mittal, Shilpi,Malde, Alpeshkumar,Selvam,Arun,Johar,Jachak, Sanjay M.,Ramarao,Bharatam,Chawla
, p. 979 - 982 (2007/10/03)
Herein we report an efficient procedure to synthesize S-4-(3-thienyl) phenyl-α-methylacetic acid, an enantiomerically pure intermediate of a recently approved nonsteroidal antiinflammatory cyclooxygenase inhibitor, atliprofen [methyl RS-4-(3-thienyl)phenyl-α-methylacetate]. The interactions of the active S-isomer of the acid were theoretically compared with those of S-ibuprofen through molecular docking studies using COX-1 and COX-2 protein structures. The results were corroborated by in vitro and in vivo studies.
