119492-72-7

Upstream product

• 120413-98-1 4-[(4-ethyl)phenyl]-2-chlorothiophene 
• 119492-68-1 C₁₂H₁₂O₄^(2-)*2Na⁽¹⁺⁾ 
• 1019780-60-9 1-(4-thiophen-3-ylphenyl)ethanol 
• 100-41-4 ethylbenzene 

Downstream Products

• 120413-98-1 4-[(4-ethyl)phenyl]-2-chlorothiophene 
• 158837-39-9 2-chloro-4-(p-ethylphenyl)-5-phenylthiophene 
• 158837-30-0 5-chloro-3-(p-ethylphenyl)-2-iodothiophene 
• 108912-14-7 2-(4-thiophen-3-yl-phenyl)-propionic acid 
• 108912-12-5 4-(3-thienyl)phenyl-α-methylacetonitrile 
• 678173-91-6 4-(3-thienyl)-α-methylbenzylbromide 

Relevant academic research and scientific papers

B(C6F5)3-Catalyzed Hydrodesulfurization Using Hydrosilanes - Metal-Free Reduction of Sulfides

B(C6F5)3-catalyzed hydrodesulfurization of carbon-sulfur bonds was achieved using triethylsilane as the reducing agent. The corresponding products were obtained in good yields under mild reaction conditions. This protocol could be applied to the reduction of sulfides, including benzyl and alkyl sulfides and dithianes, with high chemoselectivities. (Chemical Equation Presented).

Synthesis and evaluation of S-4-(3-thienyl)phenyl-α-methylacetic acid

Herein we report an efficient procedure to synthesize S-4-(3-thienyl) phenyl-α-methylacetic acid, an enantiomerically pure intermediate of a recently approved nonsteroidal antiinflammatory cyclooxygenase inhibitor, atliprofen [methyl RS-4-(3-thienyl)phenyl-α-methylacetate]. The interactions of the active S-isomer of the acid were theoretically compared with those of S-ibuprofen through molecular docking studies using COX-1 and COX-2 protein structures. The results were corroborated by in vitro and in vivo studies.

Synthesis of unsymmetrical 2,3-diaryl- and 2,4-diarylthiophenes starting from 2,5-dichlorothiophene

Unsymmetrically substituted 2,4-diaryl- and 2,3-diarylthiophenes were synthesized from 2,5-dichlorothiophene via 4-aryl-2-chlorothiophenes in two and four steps including Ni-mediated cross-coupling, respectively. Aluminum chloride-catalyzed reaction of 3-aryl-2-chlorothiophenes with some aromatic ethers unexpectedly led to the formation of the corresponding 2,4-isomers.

A New and Simple Route to 3-Arylthiophenes

3-Arylthiophenes were prepared from 2,5-dichlorothiophene in two steps. 2,5-Dichlorothiophene reacted regioselective with various aromatic compounds in the presence of AlCl3 under mild conditions to give 4-aryl-2-chlorothiophenes.The latter compounds were easily converted to the corresponding 3-arylthiophenes by catalytic dechloronation in good yields.

A High Yielding Synthesis of 3-Arylthiophenes Under Phase-Tranfer Conditions

A convenient, high-yield method for the large-scale preparation of 3-arylthiophenes by phase-transfer catalyzed (PTC) cyclization of disodium 2-arylsuccinates in o-dichlorobenzene using a mixture of diphosphorus pentasulfide and red phosphorous is described.