108915-08-8

Basic information

• Product Name: 2-[(4S)-4,5-dihydro-4-(phenylMethyl)-2-oxazolyl]- Pyridine
• Synonyms: 2-[(4S)-4,5-dihydro-4-(phenylMethyl)-2-oxazolyl]- Pyridine;(S)-2-(4-Benzyl-4,5-dihydro-oxazol-2-yl)-pyridine;2-[(4S)-4,5-Dihydro-4-(phenylmethyl)-2- oxazolyl]pyridine,99%e.e.
• CAS NO: 108915-08-8
• Molecular Formula: C₁₅H₁₄N₂O
• Molecular Weight: 238.28446
• Mol File: 108915-08-8.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 220-230 °C(Press: 0.1 Torr)
• Appearance: /
• Density: 1.16±0.1 g/cm3(Predicted)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 3.73±0.70(Predicted)
• CAS DataBase Reference: 2-[(4S)-4,5-dihydro-4-(phenylMethyl)-2-oxazolyl]- Pyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-[(4S)-4,5-dihydro-4-(phenylMethyl)-2-oxazolyl]- Pyridine(108915-08-8)
• EPA Substance Registry System: 2-[(4S)-4,5-dihydro-4-(phenylMethyl)-2-oxazolyl]- Pyridine(108915-08-8)

Safety Data

• Statements: 36/37/38
• Safety Statements: 26-36/37/39
• Hazardous Substances Data: 108915-08-8(Hazardous Substances Data)

Usage

General Description

2-[(4S)-4,5-dihydro-4-(phenylMethyl)-2-oxazolyl]- Pyridine is a chemical compound that belongs to the class of pyridine derivatives. It is a synthetic compound with a molecular formula C14H14N2O and a molecular weight of 226.3 g/mol. 2-[(4S)-4,5-dihydro-4-(phenylMethyl)-2-oxazolyl]- Pyridine has a structure consisting of a pyridine ring fused to a 2-oxazolyl group, with a phenylmethyl side chain attached to the oxazolyl group. It is commonly used in medicinal chemistry research for the development of new pharmaceuticals, especially in the field of drug discovery. Its potential biological activities and therapeutic properties make it a subject of interest for further studies in the pharmaceutical industry.

Upstream product

• 100-70-9 2-Cyanopyridine 
• 5267-64-1 (R)-2-amino-3-phenylpropanol 
• 1452-77-3 pyridine-2-carboxylic acid amide 
• 3182-95-4 L-Phenylalaninol 
• 19547-38-7 methyl pyridine-2-imidate 
• 109-04-6 2-bromo-pyridine 
• 75866-71-6 (4S)-4-benzyl-4,5-dihydro-1,3-oxazole 
• 109-09-1 2-chloropyridine 

Downstream Products

• 98-98-6 2-Picolinic acid 
• 3182-95-4 L-Phenylalaninol 

Relevant articles and documents

Copper(II) complexes of pyridine-oxazoline (Pyox) ligands: Coordination chemistry, ligand stability, and catalysis

The coordination chemistry of copper(II) complexes bearing pyridine-oxazoline ("Pyox") ligands has been studied, with an aim of investigating their catalytic ability. Interestingly, the stability of the coordinated ligands has been shown to be much less than previously assumed: hydrolysis of the ligands by fortuitous water gives rise to 2-pyridine carboxylate formation, which encapsulate the copper in a two-dimensional coordination polymer 3. The complexes [Cu(R-Pyox)(NCMe)2(ClO4)2] {R = benzyl (Bn) 2a, phenyl (Ph) 2b, isopropyl (iPr) 2c} have been prepared, of which the benzyl derivative has been analysed by CW EPR spectroscopy. The complex [Cu(Bn-Pyox)(NCMe)2(ClO4)2] and the afore-mentioned coordination polymer have been crystallographically characterised. The performance of complexes 2a-c in the asymmetric allylic oxidation of cyclohexene is described.

Parallel screening of asymmetric bidentate ligands in zinc catalyzed transfer hydrogenation

Development in the field of asymmetric catalysis is driven by the importance of stereochemically pure compounds in the field of pharmaceutical industry, agrochemicals and flavors. The unpredictable results given by new catalysts make the design of effecti

Rapid, in situ synthesis of bidentate ligands: Chromatography-free generation of catalyst libraries

The parallel synthesis of chiral bidentate ligands and their subsequent use in situ for a catalytic process is described. The ligands thus prepared gave comparable results to those obtained when the ligands were synthesized and purified by conventional means. This includes oxazolines and other compounds of similar complexity, meaning that for the first time these valuable compounds have been brought into the field of combinatorial catalysis.