108930-17-2 Usage
Uses
Used in Research Applications:
H-7 DIHYDROCHLORIDE is used as a selective inhibitor of protein kinase C or cyclic-nucleotide-dependent protein kinases for studying their roles in cellular processes and signaling pathways.
Used in Cell Biology Studies:
H-7 DIHYDROCHLORIDE is used as a kinase inhibitor to study H-7-induced inhibition of contractility in rat embryo fibroblasts (REF52) cells, providing insights into the regulation of cell contractility and its implications in various biological processes.
Used in Cancer Research:
H-7 DIHYDROCHLORIDE is used as a potent inhibitor of various kinases in cancer research, particularly in the study of HL-60 human promyelocytic leukemia cells, where it induces apoptotic DNA fragmentation and cell death.
Used in Drug Development:
H-7 DIHYDROCHLORIDE is used as a chemical probe in the development of new drugs targeting kinases, which are often dysregulated in various diseases, including cancer and other proliferative disorders.
Used in Telomerase Inhibition Studies:
H-7 DIHYDROCHLORIDE is used as an inhibitor of telomerase activity in quercetin-, H-89-, or herbimycin A-treated NPC-076 cells, contributing to the understanding of telomerase regulation and its role in cellular aging and cancer progression.
Biochem/physiol Actions
Target Ki: 3.0 μM, 97 μM, 6.0 μM, 5.8 μM against protein kinase A , myosin light chain kinase, protein kinase C , and protein kinase G, respectively
Check Digit Verification of cas no
The CAS Registry Mumber 108930-17-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,0,8,9,3 and 0 respectively; the second part has 2 digits, 1 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 108930-17:
(8*1)+(7*0)+(6*8)+(5*9)+(4*3)+(3*0)+(2*1)+(1*7)=122
122 % 10 = 2
So 108930-17-2 is a valid CAS Registry Number.
InChI:InChI=1/C14H17N3O2S.ClH/c1-11-9-16-7-8-17(11)20(18,19)14-4-2-3-12-10-15-6-5-13(12)14;/h2-6,10-11,16H,7-9H2,1H3;1H
108930-17-2Relevant academic research and scientific papers
Treatment of amyloidosis associated with Alzheimer disease using modulators of protein phosphorylation
-
, (2008/06/13)
A method of regulating phosphorylation of proteins involved in controlling processing or function of key proteins found in intracellular neurofibrillary tangles and extracellular amyloid plaques associated with Alzheimer disease comprising introducing an effective amount of a kinase modulator or phosphatase modulator, the modulator capable of increasing or decreasing the rate of proteolytic processing, or modulating the function, of said key proteins.
