108930-57-0

Upstream product

• 123485-93-8 2-(4-Methoxy-benzylsulfanyl)-4-methyl-6-(3-nitro-phenyl)-6H-pyrimidine-1,5-dicarboxylic acid diethyl ester 
• 39562-16-8 ethyl (Z)-2-(3-nitrobenzylidene)-3-oxobutanoate 
• 541-41-3 chloroformic acid ethyl ester 
• 17356-08-0 thiourea 
• 106720-60-9 1,4-dihydro-2-methoxy-6-methyl-4-(3-nitrophenyl)-5-pyrimidinecarboxylic acid ethyl ester 
• 108931-96-0 1,4-Dihydro-2-[[(4-methoxyphenyl)methyl]-thio]-6-methyl-4-(3-nitrophenyl)-5-pyrimidinecarboxylic acid,ethyl ester 
• 914915-59-6 ethyl 6-methyl-4-(3-nitrophenyl)-2-thioxo-1,2,3,4-tetrahydropyrimidin-5-carboxylate 

Relevant academic research and scientific papers

Highly versatile solid phase synthesis of biofunctional 4-aryl-3,4- dihydropyrimidines using resin-bound isothiourea building blocks and multidirectional resin cleavage

A series of pharmacologically active, functionalized 4-aryl-3,4- dihydropyrimidine-5-carboxylates (DHPMs) are prepared by a versatile novel solid phase approach. In the key step, a polymer-bound thiouronium salt is condensed with unsaturated β-ketoesters. The resulting polymer bound 1,4- dihydropyrimidines are cleaved from the resin employing multidirectional resin cleavage strategies.

2-thio or oxo-4-aryl or heterocyclo-1,5(2H)-pyrimidinedicarboxylic acid diesters and 3-acyl-5-pyrimidinecarboxylic acids and esters

Pyrimidine compounds of the formula STR1 wherein X is sulfur or oxygen, Y is R11 or --O--R1, and R4 is aryl or heterocyclo are disclosed. These compounds are useful as cardiovascular agents, particularly anti-hypertensive