108931-96-0

Upstream product

• 39562-16-8 ethyl (Z)-2-(3-nitrobenzylidene)-3-oxobutanoate 
• 25985-08-4 2-(4-methoxybenzyl)isothiourea hydrochloride 
• 106720-60-9 1,4-dihydro-2-methoxy-6-methyl-4-(3-nitrophenyl)-5-pyrimidinecarboxylic acid ethyl ester 
• 6258-60-2 p-methoxybenzylmercaptan 
• 824-94-2 p-methoxybenzyl chloride 
• 108-20-3 di-isopropyl ether 

Downstream Products

• 123485-94-9 1,4-dihydro-2-<<(4-methoxyphenyl)methyl>thio>-6-methyl-4-(3-nitrophenyl)-1-propyl-5-pyrimidinecarboxylic acid ethyl ester 
• 123486-08-8 1,6-dihydro-2-<<(4-methoxyphenyl)methyl>thio>-4-methyl-6-(3-nitrophenyl)-1-propyl-5-pyrimidinecarboxylic acid ethyl ester 
• 108932-33-8 1,6-Dihydro-2-[[(4-methoxyphenyl)methyl]thio]-4-methyl-6-(3-nitrophenyl)-1-[(4-nitrophenyl) carbonyl]-5-pyrimidinecarboxylic acid, ethyl ester 
• 108932-32-7 1,6-dihydro-2-[[(4-methoxyphenyl)methyl]thio]-4-methyl-6-(3-nitrophenyl)-1-[(4-methoxyphenyl)carbonyl]-5-pyrimidinecarboxylic acid, ethyl ester 
• 108932-34-9 1-Benzoyl-1,6-dihydro-2-[[(4-methoxyphenyl) methyl]thio]-4-methyl-6-(3-nitrophenyl)-5-pyrimidinecarboxylic acid, ethyl ester 
• 108932-04-3 2-[[(4-methoxyphenyl)methyl]thio]-4-methyl-6-(3-nitrophenyl)-1,5(6H)-pyrimidinedicarboxylic acid, 5-ethyl 1-(phenylmethyl) ester 
• 123486-07-7 1,6-dihydro-2-[[(4-methoxyphenyl)methyl]thio]-4-methyl-1-[(dimethylamino)carbonyl]-6-(3-nitrophenyl)-5-pyrimidinecarboxylic acid, ethyl ester 
• 110926-35-7 1,2,3,4-tetrahydro-6-methyl-3-(methylsulfonyl)-4-(3-nitrophenyl)-2-thioxo-5-pyrimidinecarboxylic acid ethyl ester 
• 123485-97-2 1-<<(dimethylamino)thioxo>methyl>-1,2,3,6-tetrahydro-4-methyl-6-(3-nitrophenyl)-2-thioxo-5-pyrimidinecarboxylic acid ethyl ester 
• 112795-80-9 1-<(dimethylamino)carbonyl>-1,2,3,6-tetrahydro-4-methyl-6-(3-nitrophenyl)-2-thioxo-5-pyrimidinecarboxylic acid ethyl ester 
• 108930-57-0 3,6-dihydro-4-methyl-6-(3-nitrophenyl)-2-thioxo-1,5(2H)-pyrimidinedicarboxylic acid bis(ethyl ester) 
• 123485-98-3 1,2,3,6-tetrahydro-4-methyl-6-(3-nitrophenyl)-1-propyl-2-thioxo-5-pyrimidinecarboxylic acid ethyl ester 
• 112080-32-7 3-Benzyl-6-methyl-4-(3-nitro-phenyl)-2-oxo-1,2,3,4-tetrahydro-pyrimidine-5-carboxylic acid ethyl ester 
• 112080-26-9 3-Benzyl-6-methyl-4-(3-nitro-phenyl)-2-thioxo-1,2,3,4-tetrahydro-pyrimidine-5-carboxylic acid ethyl ester 

Relevant academic research and scientific papers

2-thio or oxo-4-aryl or heterocyclo-1,5(2H)-pyrimidinedicarboxylic acid diesters and 3-acyl-5-pyrimidinecarboxylic acids and esters

Pyrimidine compounds of the formula STR1 wherein X is sulfur or oxygen, Y is R11 or --O--R1, and R4 is aryl or heterocyclo are disclosed. These compounds are useful as cardiovascular agents, particularly anti-hypertensive

1,2,3,4-Tetrahydro-6-substituted-4-aryl(or heterocyclo)-3-((substituted amino)carbonyl)-2-thioxo (or oxo)-5-pyrimidinecarboxylic acids and esters

Cardiovascular activity is exhibited by compounds having the formula STR1 and pharmaceutically acceptable salts thereof wherein X is oxygen or sulfur; R is hydrogen, alkyl, cycloalkyl, aryl, or arylalkyl and R1 is hydrogen, alkyl, cycloalkyl, a

SYNTHESIS OF SUBSTITUTED 1,2,3,4-TETRAHYDRO-6-METHYL-2-THIOXO-5-PYRIMIDINECARBOXYLIC ACID ESTERS

Substituted 1,2,3,4-tetrahydro-6-methyl-2-thioxo-5-pyrimidinecarboxylic acid esters are prepared in high overall yield from 2-methylene-3-oxobutanoic acid esters and 2-(4-methoxybenzyl)-2-thiopseudourea hydrochloride.

1,2,3,4-tetrahydro-6-substituted-4-aryl-3-substituted-2-thioxo(or oxo)-5-pyrimidinecarboxylic acids and esters and use thereof to lower blood pressure

Cardiovascular activity is exhibited by compounds having the formula STR1 and pharmaceutically acceptable salts thereof wherein X is oxygen or sulfur; R1 is alkyl, cycloalkyl, alkenyl, alkynyl, aryl --(CH2)n --Y2/sub