108931-48-2

Upstream product

• 68064-64-2 2-<(2,3-dichlorophenyl)methylene>-3-oxobutanoic acid ethyl ester 
• 29427-58-5 O-methylisourea hemisulfate 

Downstream Products

• 112080-30-5 Ethyl 4-(2,3-dichlorophenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate 
• 108930-59-2 3,6-Dihydro-4-methyl-6-(2,3-dichlorophenyl)-2-oxo-1,5(2H)-pyrimidinedicarboxylic acid, diethyl ester 
• 108931-61-9 6-(2,3-dichlorophenyl)-2-methoxy-4-methyl-1,5(6H)-pyrimidinedicarboxylic acid, 5-ethyl 1-[2-[methyl(phenylmethyl)amino]ethyl]ester 
• 108930-78-5 6-(2,3-dichlorophenyl)-3,6-dihydro-4-methyl-2-oxo-1,5(2H)-pyrimidinedicarboxylic acid, 5-ethyl 1-(phenylmethyl) ester 
• 108930-71-8 6-(2,3-dichlorophenyl)-3,6-dihydro-4-methyl-2-oxo-1,5(2H)-pyrimidinedicarboxylic acid, 5-ethyl 1-methyl ester 

Relevant academic research and scientific papers

2-thio or oxo-4-aryl or heterocyclo-1,5(2H)-pyrimidinedicarboxylic acid diesters and 3-acyl-5-pyrimidinecarboxylic acids and esters

Pyrimidine compounds of the formula STR1 wherein X is sulfur or oxygen, Y is R11 or --O--R1, and R4 is aryl or heterocyclo are disclosed. These compounds are useful as cardiovascular agents, particularly anti-hypertensive

SYNTHESIS OF SUBSTITUTED 1,2,3,4-TETRAHYDRO-6-METHYL-2-OXO-5-PYRIMIDINECARBOXYLIC ACID ESTERS: THE BIGINELLI CONDENSATION REVISITED

A general synthesis of substituted 1,2,3,4-tetrahydro-6-methyl-2-oxo-5-pyrimidinecarboxylic acid esters from 2-methylene-3-oxobutanoic acid esters and O-methylisourea hydrogen sulfate is reported.