29427-58-5Relevant articles and documents
Preparation method of O-methyl isourea sulphate
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Paragraph 0012, (2016/12/01)
The invention discloses a preparation method of O-methyl isourea sulphate. Reaction is divided into two process, a first process comprises the steps of adding urea and dimethyl sulphate into a reactor, mixing, then adding water and sulphuric acid, and carrying out reaction in the first process; and a second process comprises the steps of directly adding calcium hydroxide solid into a reaction liquid obtained in the first process in the reactor for carrying out reaction in the second process, and adding methyl alcohol after the reaction in the second process is completed for carrying out recrystallization, and filtering, so that the product O-methyl isourea sulphate is obtained. The total yield of the reactions in the two processes is more than 80%, and mass content of the product O-methyl isourea sulphate is more than 98%. The preparation method of the O-methyl isourea sulphate has the advantages that the reaction process is a 'quasi-one pot method' reaction, technology is simple, raw materials are available, solvent usage amount is small, operation is easy and yield is high; meanwhile, calcium hydroxide is adopted as the catalyst, fewer three wastes are produced in a preparation process, and environmental protection is facilitated; and a byproduct calcium sulphate can be applied to cement production, and comprehensive cost is further reduced, thereby being applicable to industrialized production.
Selective binding and analysis of macromolecules
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Page 19-20, (2008/06/13)
There is disclosed a method for selectively binding micromolecules having a lysine functionality comprising the steps of: providing a sample containing one or more species of macromolecules, each having a lysine functionality; providing a binding reagent having the formula X-NH-C(=NH)-OR or X-L-NH-C(=NH)-OR where X is an affinity label that selectively binds to a capture reagent, R is a residue group, and L is a linker moiety; introducing the binding reagent to the sample so as to effect a guanidination reaction between the binding reagent and said one or more species of macromolecules, thereby producing one or more affinity label containing homoarginine derivatives; optionally modifying the affinity label containing homoarginine derivatives to produce further affinity label containing homoarginine derivatives; and capturing affinity label containing homoarginine derivatives using the capture reagent that selectively binds X.
