108944-90-7

Upstream product

• 62890-98-6 2,5-dimethoxyphenylmagnesium bromide 
• 108905-41-5 (1S,2R,4aR,8aR)-5,5,8a-Trimethyl-2-((R)-1-naphthalen-1-yl-ethylcarbamoyloxy)-decahydro-naphthalene-1-carboxylic acid methyl ester 
• 59633-92-0 (1R,2R,4aR,8aR)-(-)-1-(p-tosyloxy)methyl-2-hydroxy-5,5,8a-trimethyldecahydronaphthalene 
• 108944-85-0 (1S,2R,4aR,8aR)-(-)-methyl 2-hydroxy-5,5,8a-trimethyldecahydronaphthalene-1-carboxylate 
• 108944-87-2 (1R,2R,4aR,8aR)-(-)-1-hydroxymethyl-2-hydroxy-5,5,8a-trimethyldecahydronaphthalene 
• 108888-69-3 (1R,4aR,8aR)-(+)-1-(p-tosyloxy)methyl-2-oxo-5,5,8a-trimethyldecahydronaphthalene 
• 59684-77-4 (+/-)-8-oxo-12-nordriman-11-acid methyl ester 
• 65754-79-2 (+/-)-methyl (1β,2β,4aα,8aβ)-2-hydroxy-decahydro-5,5,8a-trimethylnaphthalene-1-carboxylate 
• 56523-17-2 methyl 3-oxo-7,11-dimethyl-dodeca-6,10-dienoate 
• 3796-70-1 trans geranyl acetone 
• 211053-86-0 (3R,4aS,6aR,10aR,10bR)-7,7,10a-Trimethyl-3-phenyl-decahydro-naphtho[2,1-d][1,3]dioxine 
• 211053-91-7 (4aR,5S,6S,8aR)-6-Benzyloxy-5-bromomethyl-1,1,4a-trimethyl-decahydro-naphthalene 
• 211053-87-1 ((1R,2S,4aR,8aR)-2-Benzyloxy-5,5,8a-trimethyl-decahydro-naphthalen-1-yl)-methanol 
• 211053-92-8 (+)-(1S,2S,4aS,8aS)-1-bromomethyl-2-hydroxy-decahydro-5,5,8a-trimethylnaphthalene 

Downstream Products

• 69880-60-0 (+)-zonarol dimethyl ether 
• 39707-56-7 (+)-zonarone 
• 39707-54-5 (+)-zonarol 

Relevant academic research and scientific papers

Synthesis of decalin type chiral synthons based on enzymatic functionalisation and their application to the synthesis of (-)-ambrox and (+)-zonarol

Stereoselective syntheses of (-)-ambrox 2 and (+)-zonarol 3 were achieved based on the enzymatic syntheses of (8aS)- and (8aR)-decalin-type 1,3-diols 1, respectively. Non-racemic intermediates such as (8aS)-1 and (8aR)-1 were obtained based on the enantioselective hydrolyses of the phenolic acetal derivative (±)-7 by acylase I.