62890-98-6

Usage

Uses

Used in Organic Synthesis:
2,5-Dimethoxyphenylmagnesium bromide is used as a reagent for the formation of carbon-carbon bonds in Grignard reactions. It is particularly valuable for the addition of the 2,5-dimethoxyphenyl group to various substrates, facilitating the synthesis of complex organic molecules.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 2,5-Dimethoxyphenylmagnesium bromide is utilized as a key intermediate in the synthesis of certain pharmaceutical compounds, contributing to the development of new drugs and medicinal agents.
Used in Chemical Research:
2,5-Dimethoxyphenylmagnesium bromide is employed as a research tool in chemical laboratories for studying reaction mechanisms and exploring the scope and limitations of Grignard reagents in organic chemistry.
Used in Material Science:
In material science, 2,5-Dimethoxyphenylmagnesium bromide may be used in the synthesis of novel materials with specific properties, such as polymers or organic semiconductors, by incorporating the 2,5-dimethoxyphenyl group into their structures.

InChI:InChI=1/C8H9O2.BrH.Mg/c1-9-7-3-5-8(10-2)6-4-7;;/h3-5H,1-2H3;1H;/q;;+1/p-1/rC8H9BrMgO2/c1-11-6-3-4-8(12-2)7(5-6)10-9/h3-5H,1-2H3

Upstream product

• 150-78-7 1,4-dimethoxybezene 
• 25245-34-5 1-bromo-2,5-dimethoxybenzene 

Downstream Products

• 90421-02-6 (2,5-dimethoxyphenyl)(methyl)(phenyl)phosphine oxide 
• 219590-17-7 1-iodo-8-(2,5-dimethoxyphenyl)naphthalene 
• 758692-19-2 3-[(E)-5-(2,5-Dimethoxy-phenyl)-3-methyl-pent-3-enyl]-2,2-dimethyl-oxirane 
• 365525-97-9 5-chloro-3-hydroxy-3-(2,5-dimethoxyphenyl)-1,3-dihydro-2H-indol-2-one 
• 1428266-77-6 3-(2,5-dimethoxyphenyl)but-3-enoic acid 
• 915304-99-3 3-[(3E,7E)-9-(2,5-Dimethoxy-phenyl)-3,7-dimethyl-nona-3,7-dienyl]-2,2-dimethyl-oxirane 

Relevant academic research and scientific papers

Copper-catalyzed difluoromethylation of β,γ-unsaturated carboxylic acids: An efficient allylic difluoromethylation

Not one but two! A new strategy for the regiospecific construction of compounds with allylic CF2H groups has been developed. The decarboxylative (phenylsulfonyl)difluoromethylation of β,γ- unsaturated carboxylic acids is catalyzed by a Lewis acid (CuCl 2·2 H2O), and the resulting product easily undergoes desulfonylation. Copyright

CHIRAL PHOSPHORUS COMPOUNDS

The present invention provides P-chiral compounds of general formula (II) and (III): wherein at least one of R21, R25, R26 and R30 is independently selected from C1-4 alkyl, CF3, C1-4 alkoxy, phenyl and benzyloxy and the remaining substituents selected from R21, R25, R26 and R30 are hydrogen; at least one of R22, R24, R27 and R29 are independently selected from C1-4 alkyl, CF3, C1-4 alkoxy, phenyl and benzyloxy and the remaining substituents selected from R22, R24, R27 and R29 are hydrogen; and R23 and R28 are independently selected from hydrogen, C1-4 alkyl, CF3, C1-4 alkoxy, phenyl and benzyloxy; Formula (III): wherein at least one of R21, R25, R26 and R30 is independently selected from phenyl and benzyloxy and the remaining substituents selected from R21, R25, R26 and R30 are hydrogen; and R22, R23, R24, R27, R28 and R29 are independently selected from hydrogen, C1-4 alkyl, CF3, C1-4 alkoxy, phenyl and benzyloxy.wherein at least one of R21, R25, R26 and R30 is independently selected from phenyl and benzyloxy and the remaining substituents selected from R21, R25, R26 and R30 are hydrogen; and R22, R23, R24, R27, R28 and R29 are independently selected from hydrogen, C1-4 alkyl, CF3, C1-4 alkoxy, phenyl and benzyloxy.

Synthesis, X-ray structure analysis and topochemical photopolymerization of substituted 1,6-bis(2,5-dimethoxyphenyl)hexa-2,4-diynes

The 1,6-bis(2,5-dimethoxyphenyl)hexa-2,4-diynes 4a-c were obtained from the corresponding 2,5-dimethoxybenzenes 1 by bromination followed by a copper-catalyzed Grignard reaction with 3-bromoprop-1-yne. Catalyzed coupling of the resulting 3-(2,5-dimethoxyphenyl)prop-1-ynes 3 under Hay conditions gave the hexa-2,4-diynes 4a-c in good yields. The molecular structures of the diynes 4a and 4b were determined by X-ray diffraction analysis. In each crystal structure, an unusual 1,6-synperiplanar conformation of the hexa-2,4- diyne unit is observed, with the 1,6-diphenyl substituents arranged in a coplanar orientation. According to the crystal structure data obtained, irradiation of diynes 4a and 4b afforded the deeply-colored, highly-ordered polymers 5a and 5b under topochemical control. Oxidation of 4a and 4b with cerium(IV) ammonium nitrate gave the corresponding 1,6-bis(2,5- dimethoxyphenyl)hexa-2,4-diyne-1,6-diones 6a and 6b.

Phosphororganische Verbindungen 106. Die Synthese Optisch Aktiver Tertiaerer Phosphine und Phosphinoxide mit Ortho-Substituierten Arylliganden

Compounds of the type C6H5Y (Y=OR, -NMe2), are lithiated with n-butyllithium (n-BuLi) in the ortho-position according (1) and transformed by special reactions to compounds of the type I and II. The representatives 7-22 of the type I with Y=OR ar