1089665-70-2Relevant academic research and scientific papers
Novel C2-symmetric phenylglycine derivatives as organocatalysts of the Michael reaction between nitroalkenes and ketones
Kostenko, A. A.,Kucherenko, A. S.,Kuznetsova, O. Yu.,Zlotin, S. G.
, p. 885 - 889 (2021/06/07)
A comprehensive study of the activity of the amide-type organocatalysts based on (R)- and (S)-phenylglycine and 1,2-di(2-pyridyl)-1,2-diaminoethane in the asymmetric Michael reaction between various nitroalkenes and ketones was carried out. The products o
Asymmetric Conjugate Addition of Nitroalkanes to Enones Using a Sulfonamide-Thiourea Organocatalyst
Kawada, Masahiro,Nakashima, Kosuke,Hirashima, Shin-Ichi,Yoshida, Akihiro,Koseki, Yuji,Miura, Tsuyoshi
, p. 6986 - 6991 (2017/07/15)
The asymmetric conjugate addition of nitroalkanes to α,β-unsaturated ketones in the presence of a catalytic amount of a novel sulfonamide-thiourea organocatalyst resulted in the corresponding γ-nitro carbonyl products in high yields with excellent enantio
Highly Enantioselective Michael Addition of Nitroalkanes to Enones and Its Application in Syntheses of (R)-Baclofen and (R)-Phenibut
Guo, Xing-Tao,Shen, Jie,Sha, Feng,Wu, Xin-Yan
, p. 2063 - 2072 (2015/07/15)
A highly enantioselective Michael addition of nitroalkanes to α,β-unsaturated ketones was developed. In the presence of a chiral primary amine-thiourea catalyst based on dehydroabietic amine, γ-nitro ketones were obtained with excellent enantioselectiviti
Modularly designed organocatalytic assemblies for direct nitro-Michael addition reactions
Mandal, Tanmay,Zhao, Cong-Gui
scheme or table, p. 7714 - 7717 (2009/04/10)
It's so simple! Organocatalysts formed through the self-assembly of simple α-amino acids and alkaloid thiourea derivatives (see scheme) are used as highly efficient catalysts for the direct nitro-Michael addition of ketones and nitroalkenes, affording excellent ee values up to 99%. Enantioselectivity may be tuned by changing components of the self-assembled catalyst.
